Protein Alignment CG13796 and SLC6A3

DIOPT Version :10

• Sequence 1: NP_609140.2
• Gene: CG13796 / 34051
• FlyBaseID: FBgn0031939
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 152/607 - (25%)
• Similarity: 244/607 - (40%)
• Gaps: 123/607 - (20%)

  Fly    84 RGRWAKSADFYFASCTHAFSSLIFSELSTFGIL---HGGWLLFIIAYLMGMLFYSLPIFLIQAFL 145
            |..|.|..||..:....|..   .:.:..|..|   :||. .|::.||:.|:...:|:|.::..|
Human    60 RETWGKKIDFLLSVIGFAVD---LANVWRFPYLCYKNGGG-AFLVPYLLFMVIAGMPLFYMELAL 120

  Fly   146 GQFSSSGTISAFRVAPIFKGIGYAILLLNLGTLTYYSIAAVVPLIYTVNSIHPVIPWMSCNNSWN 210
            |||:..|....:::.||.||:|:.::|::|....:|::.....|.|..:|....:||:.||||||
Human   121 GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWN 185

  Fly   211 TQECS---------------------------------LHENYDVDDYRVDPHSTVEFFRSMIA- 241
            :..||                                 ||:::.:||..............:|.
Human   186 SPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVL 250

  Fly   242 ---STAKG-STSMSISWSMLIGVLSIWLVVLALLLKPVAFIGKV--LRCSCVLMFGFFVAVFLYL 300
               |..|| .||..:.|   |.....::|:.||||:.|...|.:  :|.        :::|..|.
Human   251 LYFSLWKGVKTSGKVVW---ITATMPYVVLTALLLRGVTLPGAIDGIRA--------YLSVDFYR 304

  Fly   301 LIHEQVTFDTLHYYWMPQLDSFDSILATARTALLMAGGALGPGWGSIITLSSYNNFRRDAERLSI 365
            |....|..|                   |.|.:..   :||.|:|.:|..||||.|..:..|.:|
Human   305 LCEASVWID-------------------AATQVCF---SLGVGFGVLIAFSSYNKFTNNCYRDAI 347

  Fly   366 WV----CLTHITIG-----LMGLLCCNVAHDHFEDHVGMMPLHVDEKHHMQFLYLCFSYLFGRFT 421
            ..    .||..:.|     .:|.:    |..|      .:|:....|.....:::.:.   ....
Human   348 VTTSINSLTSFSSGFVVFSFLGYM----AQKH------SVPIGDVAKDGPGLIFIIYP---EAIA 399

  Fly   422 TTP--NLWAFLFFGMIFLSELCALIIQMMSVITALFDEFETLRSRRILVISSLVFCLTASSVYFC 484
            |.|  :.||.:||.|:....:.:.:..|.||||.|.|||:.|...|.|....:|......|::..
Human   400 TLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCV 464

  Fly   485 TQLGFSQLTQLPNLAVFTHLLISGILV--LMTTWVYGRVRFQCDLQFMLGKTISSFKIFFIRFAT 547
            |..|....|.|.:.|..|.:|. |:|:  :...|.||..:|..|:|.|.|:..|.:.....:..:
Human   465 TNGGIYVFTLLDHFAAGTSILF-GVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVS 528

  Fly   548 PIFLGLCLFQLTYLFTRDRIHDVLIYV------SQGLILLTAISYMV-----YKVCRTNGDWRQR 601
            |.||   ||.:.......|......|:      :.|.::.|:...||     ||.|...|.:|::
Human   529 PCFL---LFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREK 590

  Fly   602 LQQCLAPH-DWHPVD-ADNRRF 621
            |...:||. |...|| .:.|:|
Human   591 LAYAIAPEKDRELVDRGEVRQF 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13796	NP_609140.2	SLC5-6-like_sbd	123..610	CDD:444915	137/551 (25%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	152/607 (25%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		9/28 (32%)