Protein Alignment CG13796 and SLC6A1

DIOPT Version :10

• Sequence 1: NP_609140.2
• Gene: CG13796 / 34051
• FlyBaseID: FBgn0031939
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 158/597 - (26%)
• Similarity: 254/597 - (42%)
• Gaps: 101/597 - (16%)

  Fly    75 ERPYRHDK----------------CRGRWAKSADFYFASCTHAFSSLIFSELSTFGILHG--GWL 121
            |.|..:||                .|..|....||..:...:|..   ...:..|..|.|  |..
Human    19 EAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIG---LGNVWRFPYLCGKNGGG 80

  Fly   122 LFIIAYLMGMLFYSLPIFLIQAFLGQFSSSGTISAFRVAPIFKGIGYAILLLNLGTLTYYSIAAV 186
            .|:|.|.:.::|..:|:||::..|||::|.|.:..:::||:|||:|.|..:|:.....||.:...
Human    81 AFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIIS 145

  Fly   187 VPLIYTVNSIHPVIPWMSCNNSWNTQECSLHENYDVDDYRVDPHSTVEFF-RSMIASTAKGSTSM 250
            ..:.|..||....:||..|:|.|||..|  ..||.:.:......:.|||: |:|...|.......
Human   146 WAIYYLYNSFTTTLPWKQCDNPWNTDRC--FSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPG 208

  Fly   251 SISWSMLIGVLSIWLVVLALLLKPVAFIGKVLRCSCVLMFGFFVAVFLYLLIHEQVTF----DTL 311
            .|.|.:.|.:...|::|...:.|.|.:.|||:..|....:     :.|.:|....||.    :.:
Human   209 QIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPY-----IMLIILFFRGVTLPGAKEGI 268

  Fly   312 HYYWMPQLD--SFDSILATARTALLMAGGALGPGWGSIITLSSYNNFRRDAERLSIWV-CLTHIT 373
            .:|..|...  |...:...|.|.:..   :.|.|.||:|.|.|||:|..:..|.||.| |:...|
Human   269 LFYITPNFRKLSDSEVWLDAATQIFF---SYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCT 330

  Fly   374 IGLMGLLCCNVAHDHFEDHVGMMPLHVDEKHHMQ-------FLYLCFSYLFGRFTTTPNLWAFLF 431
            ....|.:..::        ||.| .||.::....       ..:|.:.....:...:| |||.||
Human   331 SMFAGFVIFSI--------VGFM-AHVTKRSIADVAASGPGLAFLAYPEAVTQLPISP-LWAILF 385

  Fly   432 FGMIFLSELCALIIQMMSVITALFDEF-ETLRSRRILVISSLVFCLTASSVYFCTQLGFSQLTQ- 494
            |.|:.:..:.:....:...||||.||: ..||:||.|.|:::  |:.:   |.   :|.|.:||
Human   386 FSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAV--CIIS---YL---IGLSNITQG 442

  Fly   495 -LPNLAVFTHLLISGILVLM--------TTWVYGRVRFQCDLQFMLGKTISSFKIFFIRFATPIF 550
             :....:|.:...||:.:|.        .:|.||..||..::|.|:|.....:......|.|||.
Human   443 GIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPII 507

  Fly   551 L-GLCLF---QLT------YLFTRDRIHDVLIYVSQGLILLTAIS-------YMVYKVCRTNGDW 598
            : |:.:|   |:|      |:|.:         ..||:..|.|:|       ||.|......|..
Human   508 VAGVFIFSAVQMTPLTMGNYVFPK---------WGQGVGWLMALSSMVLIPGYMAYMFLTLKGSL 563

  Fly   599 RQRLQQCLAPHD 610
            :||:|..:.|.:
Human   564 KQRIQVMVQPSE 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13796	NP_609140.2	SLC5-6-like_sbd	123..610	CDD:444915	145/529 (27%)
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	158/597 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599