DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13796 and slc6a2

DIOPT Version :9

Sequence 1:	NP_001137807.1	Gene:	CG13796 / 34051	FlyBaseID:	FBgn0031939	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_009301625.1	Gene:	slc6a2 / 565776	ZFINID:	ZDB-GENE-110408-4	Length:	625	Species:	Danio rerio

Alignment Length:	615	Identity:	153/615 - (24%)
Similarity:	258/615 - (41%)	Gaps:	135/615 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 RGRWAKSADFYFASCTHA--------FSSLIFSELSTFGILHGGWLLFIIAYLMGMLFYSLPIFL 140
            |..|.|..||..:....|        |..|.:.        :||. .|:|.|::.:....:|:|.
Zfish    64 RETWGKKMDFLLSVIGFAVDLANVWRFPYLCYK--------NGGG-AFLIPYVLFLFIAGMPLFY 119

  Fly   141 IQAFLGQFSSSGTISAFRVAPIFKGIGYAILLLNLGTLTYYSIAAVVPLIYTVNSIHPVIPWMSC 205
            ::..|||::..|..:.:::.|:|||:||.::::.|....||::.....|.|...|:...:||:.|
Zfish   120 MELALGQYNREGAATLWKICPVFKGVGYTVIVIALYVGFYYNVIIAWSLYYLYASLTSELPWLHC 184

  Fly   206 NNSWNTQECSLHENYDVD-----------DYRVDPHSTVEFF-RSMIAS-TAKGSTSMSI-SWSM 256
            ||.||:..|:  |..|::           .|:..|  ..||: |.::.| .:||...:.: .|.
Zfish   185 NNPWNSPNCT--EPKDINGTVLGNGTSYAKYKNTP--AAEFYERGVLHSHESKGIGDLGLPRWE- 244

  Fly   257 LIGVLSIWLVVLALLL-----KPVAFIGKVLRCSCVLMFGFFVAVFLYLLIHEQVT----FDTLH 312
                |:|.|||:|.:|     |.|...|||:..:..:.:     :.|.:|:...:|    .:.:.
Zfish   245 ----LTICLVVVAFILYFSLWKGVKSSGKVVYITATMPY-----IVLLVLLIRGITLPGAMNGIR 300

  Fly   313 YYWMPQLDSFDS--ILATARTALLMAGGALGPGWGSIITLSSYNNFR----RDAERLSIWVCLTH 371
            .|....|...::  :...|.|.:..   :||.|:|.:|..||||.|.    |||...|...|:|.
Zfish   301 AYLHIDLKKLNNPQVWIDAATQIFF---SLGAGFGVLIAFSSYNKFNNNCYRDAILTSTINCVTS 362

  Fly   372 ITIG-----LMGLLCCNVAHDHFEDHVGMMPLHVDEKHHMQF-------LYLCFSYLFGRFTTTP 424
            ...|     ::|                    ::.|:|.:..       ..|.|.......:|.|
Zfish   363 FFSGFAIFSVLG--------------------YMAEQHKVNIKDVATEGAGLVFVIYPEAISTLP 407

  Fly   425 NLWAFLFFGMIFLSELCALIIQ-----MMSVITALFDEFETL-RSRRILVISSLV-------FCL 476
            ..   .||.::|...|..|.|.     |.:|:|.|.|:|:.| |:|::...:::|       .|:
Zfish   408 GA---TFFAIVFFIMLLTLGIDSSMGGMEAVLTGLSDDFKILKRNRKLFTFATVVGTFLMALLCV 469

  Fly   477 TASSVYFCTQLGFSQLTQLPNLAVFTHLLISGIL--VLMTTWVYGRVRFQCDLQFMLGKTISSFK 539
            |...:|.        ||.|...|..|.:|. |:|  .:..:|.||..||..|::.|:|.....:.
Zfish   470 TNGGIYV--------LTLLDKYAAGTSILF-GVLFEAIGVSWFYGVDRFSEDIERMMGFKPGIYW 525

  Fly   540 IFFIRFATPIFLGLCLFQLTYLFTRDRI-HD--VLIYVSQGLILLTAIS-------YMVYKVCRT 594
            ....:|.:|.|  |.|..:..:.|..|: :|  |..|.:..|....|:|       |.:||....
Zfish   526 RLCWKFVSPAF--LLLVVIASIVTSGRLTYDEYVFPYWADMLGWSIALSSMLFVPFYAIYKFFSV 588

  Fly   595 NGDWRQRLQQCLAP-HDWHPVDADNRRFYE 623
            ...:::||..|:.| |:.|.|...|.|.::
Zfish   589 PSSFKERLAYCVTPEHEHHLVAEGNVRQFK 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13796	NP_001137807.1	SLC5-6-like_sbd	123..610	CDD:294310	138/553 (25%)
slc6a2	XP_009301625.1	SLC5-6-like_sbd	64..623	CDD:294310	153/615 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920