DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13796 and SLC6A15

DIOPT Version :9

Sequence 1:	NP_001137807.1	Gene:	CG13796 / 34051	FlyBaseID:	FBgn0031939	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_877499.1	Gene:	SLC6A15 / 55117	HGNCID:	13621	Length:	730	Species:	Homo sapiens

Alignment Length:	566	Identity:	118/566 - (20%)
Similarity:	227/566 - (40%)	Gaps:	123/566 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 GGWLLFIIAYLMGMLFYSLPIFLIQAFLGQFSSSGTISAFR-VAPIFKGIGYAILLLNLGTLTYY 181
            ||  .:::.||:.::...:|:|.::..:||....|:|..:. ::|...|||:|..::......||
Human    96 GG--AYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYY 158

  Fly   182 SIAAVVPLIYTVNSIHPVIPWMSCNNSWNTQECSLHENYDVDDYRVDPH------STVEFFRSMI 240
            ::.....|.|...|....:||         .:|.|.:|  .....|:|.      :|..::|..:
Human   159 NVIIGWSLFYFSQSFQQPLPW---------DQCPLVKN--ASHTFVEPECEQSSATTYYWYREAL 212

  Fly   241 ASTAKGSTSMSISWSMLIGVLSIWLVVLALLLKPVAFIGKVLRCSC----VLMFGFFVAVFLYLL 301
            ..::..|.|..::|.|.|.:|:.|::|...::|.:...||::..|.    |::..|.:..||.
Human   213 NISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLL-- 275

  Fly   302 IHEQVTFDTLHYYWMPQLDSF--DSILATARTALLMAGGALGPGWGSIITLSSY----NNFRRDA 360
               ..:.|.:.:.:.|:|:..  ..:...|.|.:..   |||.|:|.:|..|||    ||...||
Human   276 ---NGSIDGIRHMFTPKLEIMLEPKVWREAATQVFF---ALGLGFGGVIAFSSYNKRDNNCHFDA 334

  Fly   361 ERLSI-----WVCLTHITIGLMG---------------------LLCCNVAHDHFEDHVGMMPLH 399
            ..:|.     .|..|.:...::|                     |...|::.|....|:.:..:.
Human   335 VLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVT 399

  Fly   400 VDEKH-----------------HMQ----------------FLYLCFSYLFGRFTTTPNLWAFLF 431
            .::.|                 |:.                ..::.|:.....|..:| .|:.:|
Human   400 AEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASP-FWSVMF 463

  Fly   432 FGMIFLSELCALIIQMMSVITALFDEFETLRSRRILVISSLVFCL-----TASSVYFCTQLGFSQ 491
            |.|:....|.::...:..::|.:.|.|:..:....::...|.||:     ..|..||.|......
Human   464 FLMLVNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYS 528

  Fly   492 LTQLPNLAVFTHLLISGILVLMTTWVYGRVRFQCDLQFMLGKTISSFKIFFIRFATPI-FLGLCL 555
            .| ||.|.|   :::..|.|   .:|||..:|..||:.|||...|.:..:..::.:|: .|.|.:
Human   529 AT-LPLLIV---VILENIAV---CFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLI 586

  Fly   556 FQLTYL---------FTRDRI-HDVLIYVSQGLILLTAISYMVYKV 591
            ..:..:         :..|:. .:.|.|.:.||::  .:|.:|:.:
Human   587 ASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVV--CVSLVVFAI 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13796	NP_001137807.1	SLC5-6-like_sbd	123..610	CDD:294310	116/561 (21%)
SLC6A15	NP_877499.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..60
SLC6A15	NP_877499.1	SLC6sbd_SBAT1	61..640	CDD:212091	118/566 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820