DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13796 and SLC6A20

DIOPT Version :9

Sequence 1:	NP_001137807.1	Gene:	CG13796 / 34051	FlyBaseID:	FBgn0031939	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001372612.1	Gene:	SLC6A20 / 54716	HGNCID:	30927	Length:	603	Species:	Homo sapiens

Alignment Length:	579	Identity:	128/579 - (22%)
Similarity:	228/579 - (39%)	Gaps:	134/579 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 DKCRGRWAKSADFYFASCTHAFSSLIFSELSTFGIL---HGGWLLFIIAYLMGMLFYSLPIFLIQ 142
            :|.|..||.|..|.||..::|..   ...:..|..|   :||. .|::.|::.::...:|:..::
Human     2 EKARPLWANSLQFVFACISYAVG---LGNVWRFPYLCQMYGGG-SFLVPYIIMLIVEGMPLLYLE 62

  Fly   143 AFLGQFSSSGTISAFR-VAPIFKGIGYAILLLNLGTLTYYSIAAVVPLIYTVNSIHPVIPWMSCN 206
            ..:||....|:|.|:| ::|...|:|.|.::::.....||::.......|..:|....:||..|.
Human    63 LAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCP 127

  Fly   207 NSWNTQECSLHENYDVDDYRVDPHSTVEFF--RSMIASTAKGSTSMSISWSMLIGVLSIWLVVLA 269
            .:.|      |..||.:   .:..|:.::|  |..:..:.....:..:.|...:.:|..||||..
Human   128 LNGN------HTGYDEE---CEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYL 183

  Fly   270 LLLKPVAFIGKVLRCSCVLMFGFFVAVFLY-LLIHEQVTFDTLH-------YYWMPQLDSFDSIL 326
            .:|:.....|||:         :|.|...| :||...:...|||       |.:.|:..|..|:|
Human   184 CILRGTESTGKVV---------YFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKGSSALSLL 239

  Fly   327 A-------------TARTALLMAGGALGPGWGSIITLSSYNNFRRDAERLSIWVCLTH------- 371
            |             .|.|.:..   :||.|:||:|..:|||....:.::.:|.|.|.:
Human   240 AFQIEQLANPKAWINAATQIFF---SLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFA 301

  Fly   372 --ITIGLMG---------------LLCCN--------VAHDHFEDHVGMMPLHVDEKHHMQFLYL 411
              :|..:.|               ||..|        :...:.|...|.:......|:...|..:
Human   302 SIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQI 366

  Fly   412 CFSYLFGRFTT--------------------TPNLWAFLFFGMIFLSELCALIIQMMSVITALFD 456
            ....|.....|                    ...||:.|:|.|:.:..:.:::....:::|.|.|
Human   367 KNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTD 431

  Fly   457 EFETLRSRRIL-------VISSLVFCLT--ASSVYFCTQLG------FSQLTQLPNLAVFTHLLI 506
            .       :|:       .||.|| ||.  |..:.|..:.|      |:...     |..:.|||
Human   432 S-------KIISSHLPKEAISGLV-CLVNCAIGMVFTMEAGNYWFDIFNDYA-----ATLSLLLI 483

  Fly   507 SGILVLMTTWVYGRVRFQCDLQFMLGKTISSF-KIFFIRFATPIFLGLCLFQLT-YLFT 563
            ..:..:...:|||..||:.||:.|.|:.:|.: |:.:...:..:.:.|.:|.|: |:.|
Human   484 VLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILT 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13796	NP_001137807.1	SLC5-6-like_sbd	123..610	CDD:294310	115/534 (22%)
SLC6A20	NP_001372612.1	SLC6sbd_SIT1	2..588	CDD:271401	128/579 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810