DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13796 and slc6a1b

DIOPT Version :9

Sequence 1:	NP_001137807.1	Gene:	CG13796 / 34051	FlyBaseID:	FBgn0031939	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001007363.1	Gene:	slc6a1b / 492490	ZFINID:	ZDB-GENE-041114-57	Length:	600	Species:	Danio rerio

Alignment Length:	554	Identity:	148/554 - (26%)
Similarity:	244/554 - (44%)	Gaps:	53/554 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 RGRWAKSADFYFASCTHAFSSLIFSELSTFGILHG--GWLLFIIAYLMGMLFYSLPIFLIQAFLG 146
            |..|....||..:...:|..   ...:..|..|.|  |...|:|.|.:.::|..:|:|.::..||
Zfish    43 RETWQGKFDFLLSCVGYAIG---LGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFFLETALG 104

  Fly   147 QFSSSGTISAFRVAPIFKGIGYAILLLNLGTLTYYSIAAVVPLIYTVNSIHPVIPWMSCNNSWNT 211
            |::|.|.:..:::||:|||:|.|..:|:.....||.:.....:.|..||....:||.||:|.|||
Zfish   105 QYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIIAWAIYYLYNSFTTDLPWKSCDNPWNT 169

  Fly   212 QECSLHENYDVDDYRVDPHSTVEFF-RSMIASTAKGSTSMSISWSMLIGVLSIWLVVLALLLKPV 275
            .:|  ..||.:.:......:.|||: |:|...|........|...:.|.:...|::|...:.|.|
Zfish   170 DKC--FSNYSMANIGNMTSAVVEFWERNMHQLTDGLEKPGEIRLPLAITLAIAWVLVYFCIWKGV 232

  Fly   276 AFIGKVLRCSCVLMFGFFVAVFLYLLIHEQVTF----DTLHYYWMPQLDSF--DSILATARTALL 334
            .:.|||:..|..  :.:|:   |::|....||.    :.:.:|..|:....  ..:...|.|.:.
Zfish   233 GWTGKVVYFSAT--YPYFM---LFILFIRGVTLPGAKEGILFYVTPEFSKLKESEVWLDAATQIF 292

  Fly   335 MAGGALGPGWGSIITLSSYNNFRRDAERLSIWV-CLTHITIGLMGLLCCNVAHDHFEDHVGMMPL 398
            .   :.|.|.||:|.|.|||.|..:..:.||.| |:...|....|.:..::.  .|..|:...|:
Zfish   293 F---SYGLGLGSLIALGSYNPFNNNVYKDSIIVCCINSFTSMFAGFVIFSIV--GFMAHITKRPI 352

  Fly   399 HVDEKHHMQFLYLCFSYLFGRFTTTPNLWAFLFFGMIFLSELCALIIQMMSVITALFDEF-ETLR 462
            ...........:|.:.....:...:| |||.|||.|:.:..:.:....:...||||.||| ..||
Zfish   353 ADVAASGPGLAFLAYPEAVTQLPISP-LWAVLFFSMLLMLGIDSQFCTVEGFITALVDEFPRALR 416

  Fly   463 SRRILVISSLVFCLTASSVYFCTQLGFSQLTQ--LPNLAVFTHLLISGILVLM--------TTWV 517
            .||.:.|:  |.||.:   |.   :|.|.:||  |....:|.:...||:.:|.        .:|.
Zfish   417 GRREIFIA--VVCLVS---YL---IGLSNITQGGLYVFKLFDYYSASGMCLLFLVFFECVSISWF 473

  Fly   518 YGRVRFQCDLQFMLG-KTISSFKIFFIRFATPIFLGLCLFQLTYLFTRDRIHDVLIYVSQGLILL 581
            ||..:|..:|:.|:| |....:|:.::.|...|..|:.||....:......:.|.....||:...
Zfish   474 YGVNKFYGNLEEMIGYKPCIWWKLCWVVFTPLIVAGVFLFSAVQMVPLTLNNYVFPKWGQGVGWC 538

  Fly   582 TAIS-------YMVYKVCRTNGDWRQRLQQCLAP 608
            .|:|       ||.|......|.:::||:..:.|
Zfish   539 MALSSMVLIPGYMGYMFLTLKGSYKERLRIMIQP 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13796	NP_001137807.1	SLC5-6-like_sbd	123..610	CDD:294310	139/513 (27%)
slc6a1b	NP_001007363.1	SLC5-6-like_sbd	2..600	CDD:294310	148/554 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920