DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13796 and Slc6a4

DIOPT Version :9

Sequence 1:	NP_001137807.1	Gene:	CG13796 / 34051	FlyBaseID:	FBgn0031939	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_037166.2	Gene:	Slc6a4 / 25553	RGDID:	3714	Length:	630	Species:	Rattus norvegicus

Alignment Length:	664	Identity:	165/664 - (24%)
Similarity:	288/664 - (43%)	Gaps:	119/664 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LNNCMLLGDCENSEHGTELPGDFIGEPVETESGGGMGGSLALAARRIRSRQVHS--MAVRTGSAY 71
            ||:..:|.:|::.|              :.:..|.:...:...|.|....|:.:  .||.:.||.
  Rat     6 LNSQKVLSECKDRE--------------DCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAG 56

  Fly    72 D-----------TLERPYRHDKCRGRWAKSADFYFASCTHA--------FSSLIFSELSTFGILH 117
            |           ||....|..: |..|.|..||..:...:|        |..:.:.        :
  Rat    57 DEASHSIPAATTTLVAEIRQGE-RETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQ--------N 112

  Fly   118 GGWLLFIIAYLMGMLFYSLPIFLIQAFLGQFSSSGTISAFR-VAPIFKGIGYAILLLNLGTLTYY 181
            ||. .|::.|.:..:|..:|:|.::..|||:..:|.||.:| :.||||||||||.::.....:||
  Rat   113 GGG-AFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYY 176

  Fly   182 SIAAVVPLIYTVNSIHPVIPWMSCNNSWNTQECSLHENYDV-DDYRVDPHST---VEFFRSMIAS 242
            :......|.|.::|:...:||.||.|||||..|:   ||.. |:.....|||   .||:...:..
  Rat   177 NTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCT---NYFAQDNITWTLHSTSPAEEFYLRHVLQ 238

  Fly   243 --TAKGSTSM-SISWSMLIGVLSIWLVVLALLLKPVAFIGKVLRCSCVLMFGFFVAVFLYLLIH- 303
              .:||...: :|||.:.:.::.|:.|:...:.|.|...|||:         :..|.|.|:::.
  Rat   239 IHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVV---------WVTATFPYIVLSV 294

  Fly   304 ------------EQVTFDTLHYYWMPQLDSFDSILATARTALLMAGGALGPGWGSIITLSSYNNF 356
                        ..|.| .|...|...|::...:.|.|:...     :||||:|.::..:|||.|
  Rat   295 LLVRGATLPGAWRGVVF-YLKPNWQKLLETGVWVDAAAQIFF-----SLGPGFGVLLAFASYNKF 353

  Fly   357 R----RDAERLSIWVCLTHITIGLMGLLCCNVAHDHFEDHVGMMPLHVDEKHHMQFLYLCFSYLF 417
            .    :||...|:..|:|....|.:.........:...:.|.    .|.:......|::.::...
  Rat   354 NNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVS----EVAKDAGPSLLFITYAEAI 414

  Fly   418 GRFTTTPNLWAFLFFGMIFLSELCALIIQMMSVITALFDEFETLRSRR------ILVISSL---V 473
            .....: ..:|.:||.|:....|.:....:..||||:.|||..:.::|      |:||:.:   :
  Rat   415 ANMPAS-TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSL 478

  Fly   474 FCLTASSVYFCTQLGFSQLTQLPNLAVFTHLLISGILVLMTTWVYGRVRFQCDLQFMLGKTISSF 538
            ..||:...|..|.|  .:....|  ||.|..||..:.|   :|.||..:|..|::.|||.:...|
  Rat   479 LTLTSGGAYVVTLL--EEYATGP--AVLTVALIEAVAV---SWFYGITQFCSDVKEMLGFSPGWF 536

  Fly   539 -KIFFIRFATPIFL--GLCLFQLT----YLFTRDRIH-DVLIYVSQGLILLTAI-SYMVYKVCRT 594
             :|.::.. :|:||  .:|.|.::    .||..:..| .:::....|:..:..| :|::|::..|
  Rat   537 WRICWVAI-SPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST 600

  Fly   595 NGDWRQRLQQCLAP 608
            .|..::|:.:.:.|
  Rat   601 PGTLKERIIKSITP 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13796	NP_001137807.1	SLC5-6-like_sbd	123..610	CDD:294310	139/529 (26%)
Slc6a4	NP_037166.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..60		9/36 (25%)
		5HT_transport_N	24..64	CDD:397524	9/39 (23%)
		SLC6sbd_SERT	79..615	CDD:271399	148/576 (26%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920