DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13796 and Slc6a3

DIOPT Version :9

Sequence 1:	NP_001137807.1	Gene:	CG13796 / 34051	FlyBaseID:	FBgn0031939	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_036826.1	Gene:	Slc6a3 / 24898	RGDID:	3715	Length:	619	Species:	Rattus norvegicus

Alignment Length:	596	Identity:	144/596 - (24%)
Similarity:	237/596 - (39%)	Gaps:	122/596 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 RGRWAKSADFYFASCTHA--------FSSLIFSELSTFGILHGGWLLFIIAYLMGMLFYSLPIFL 140
            |..|:|..||..:....|        |..|.:.        :||. .|::.||:.|:...:|:|.
  Rat    60 RETWSKKIDFLLSVIGFAVDLANVWRFPYLCYK--------NGGG-AFLVPYLLFMVIAGMPLFY 115

  Fly   141 IQAFLGQFSSSGTISAFRVAPIFKGIGYAILLLNLGTLTYYSIAAVVPLIYTVNSIHPVIPWMSC 205
            ::..||||:..|....:::.|:.||:|:.::|::.....:|::.....|.|..:|....:||:.|
  Rat   116 MELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC 180

  Fly   206 NNSWNTQECS--------------------------------LHENYDVDDYRVDPHSTVEFFRS 238
            ||:||:..||                                ||::..:||..............
  Rat   181 NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVL 245

  Fly   239 MIA----STAKG-STSMSISWSMLIGVLSIWLVVLALLLKPVAFIGKV--LRCSCVLMFGFFVAV 296
            :|.    |..|| .||..:.|   |.....::|:.||||:.|...|.:  :|.        :::|
  Rat   246 VIVLLYFSLWKGVKTSGKVVW---ITATMPYVVLTALLLRGVTLPGAMDGIRA--------YLSV 299

  Fly   297 FLYLLIHEQVTFDTLHYYWMPQLDSFDSILATARTALLMAGGALGPGWGSIITLSSYNNFRRDAE 361
            ..|.|....|..|                   |.|.:..   :||.|:|.:|..||||.|..:..
  Rat   300 DFYRLCEASVWID-------------------AATQVCF---SLGVGFGVLIAFSSYNKFTNNCY 342

  Fly   362 RLSIWVCLTHITIGLMGLLCCNVAHDHFEDHVGMMPLHVDEKHHMQFL-------YLCFSYLFGR 419
            |.:|      ||..:..|...:.....| ..:|.|.    :||::...       .|.|......
  Rat   343 RDAI------ITTSINSLTSFSSGFVVF-SFLGYMA----QKHNVPIRDVATDGPGLIFIIYPEA 396

  Fly   420 FTTTP--NLWAFLFFGMIFLSELCALIIQMMSVITALFDEFETLRSRRILVISSLVFCLTASSVY 482
            ..|.|  :.||.:||.|:....:.:.:..|.||||.|.|||:.|...|.|....:|......|::
  Rat   397 IATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLF 461

  Fly   483 FCTQLGFSQLTQLPNLAVFTHLLISGILV--LMTTWVYGRVRFQCDLQFMLGKTISSFKIFFIRF 545
            ..|..|....|.|.:.|..|.:|. |:|:  :...|.||..:|..|::.|.|:..:.:.....:.
  Rat   462 CVTNGGIYVFTLLDHFAAGTSILF-GVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKL 525

  Fly   546 ATPIFLGLCLFQLTYLFTRDRIHDVLIYV----SQGLILLTAISYMV-----YKVCRTNGDWRQR 601
            .:|.|| |.:..::.:..|...:...|:.    :.|.|:.|:...||     ||.|...|.:|::
  Rat   526 VSPCFL-LYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREK 589

  Fly   602 LQQCLAPHDWH 612
            |...:.|...|
  Rat   590 LAYAITPEKDH 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13796	NP_001137807.1	SLC5-6-like_sbd	123..610	CDD:294310	133/545 (24%)
Slc6a3	NP_036826.1	SLC6sbd_DAT1	60..613	CDD:212083	144/596 (24%)
Slc6a3	NP_036826.1	Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		10/28 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820