Protein Alignment CG13796 and Slc6a4

DIOPT Version :10

• Sequence 1: NP_609140.2
• Gene: CG13796 / 34051
• FlyBaseID: FBgn0031939
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_034614.2
• Gene: Slc6a4 / 15567
• MGIID: 96285
• Length: 630
• Species: Mus musculus
• Alignment Length: 663
• Identity: 165/663 - (24%)
• Similarity: 285/663 - (42%)
• Gaps: 117/663 - (17%)

  Fly     9 LNNCMLLGDCENSE---------HGTELPGDFIGEPVETESGGGM--GGSLALAARRIRSRQVHS 62
            ||:..:|.:|::.|         .|...|.|        ::|.|.  .|..|:.:........||
Mouse     6 LNSQKVLSECKDKEDCQENGVLQKGVPTPAD--------KAGPGQISNGYSAVPSTSAGDEAPHS 62

  Fly    63 MAVRTGSAYDTLERPYRHDKCRGRWAKSADFYFASCTHA--------FSSLIFSELSTFGILHGG 119
                |.:|..||.... |...|..|.|..||..:...:|        |..:.:.        :||
Mouse    63 ----TPAATTTLVAEI-HQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQ--------NGG 114

  Fly   120 WLLFIIAYLMGMLFYSLPIFLIQAFLGQFSSSGTISAF-RVAPIFKGIGYAILLLNLGTLTYYSI 183
            . .|::.|.:..:|..:|:|.::..|||:..:|.||.: ::.||||||||||.::.....:||:.
Mouse   115 G-AFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWKKICPIFKGIGYAICIIAFYIASYYNT 178

  Fly   184 AAVVPLIYTVNSIHPVIPWMSCNNSWNTQECSLHENYDV-DDYRVDPHST---VEFFRSMIAS-- 242
            .....|.|.::|....:||.||.|||||..|:   ||.. |:.....|||   .||:...:..
Mouse   179 IIAWALYYLISSFTDQLPWTSCKNSWNTGNCT---NYFAQDNITWTLHSTSPAEEFYLRHVLQIH 240

  Fly   243 TAKGSTSM-SISWSMLIGVLSIWLVVLALLLKPVAFIGKVLRCSCVLMFGFFVAVFLYLLIH--- 303
            .:||...: :|||.:.:.::.|:.::...:.|.|...|||:         :..|.|.|:::.
Mouse   241 QSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVV---------WVTATFPYIVLSVLL 296

  Fly   304 ----------EQVTFDTLHYYWMPQLDSFDSILATARTALLMAGGALGPGWGSIITLSSYNNFR- 357
                      ..|.| .|...|...|::...:.|.|:...     :||||:|.::..:|||.|.
Mouse   297 VRGATLPGAWRGVVF-YLKPNWQKLLETGVWVDAAAQIFF-----SLGPGFGVLLAFASYNKFNN 355

  Fly   358 ---RDAERLSIWVCLTHITIGLMGLLCCNVAHDHFEDHVGMMPLHVDEKHHMQFLYLCFSYLFGR 419
               :||...|:..|:|....|.:.........:...:.|.    .|.:......|::.::.....
Mouse   356 NCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVS----EVAKDAGPSLLFITYAEAIAN 416

  Fly   420 FTTTPNLWAFLFFGMIFLSELCALIIQMMSVITALFDEFETLRSRR------ILVISSL---VFC 475
            ...: ..:|.:||.|:....|.:....:..||||:.|||..:.::|      |:||:.:   :..
Mouse   417 MPAS-TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCILGSLLT 480

  Fly   476 LTASSVYFCTQLGFSQLTQLPNLAVFTHLLISGILVLMTTWVYGRVRFQCDLQFMLGKTISSF-K 539
            ||:...|..|.|  .:....|  ||.|..||..::|   :|.||..:|..|::.|||.:...| :
Mouse   481 LTSGGAYVVTLL--EEYATGP--AVLTVALIEAVVV---SWFYGITQFCSDVKEMLGFSPGWFWR 538

  Fly   540 IFFIRFATPIFL--GLCLFQLT----YLFTRDRIHDVLIY---VSQGLILLTAISYMVYKVCRTN 595
            |.::.. :|:||  .:|.|.::    .||..:..|..:|.   :....::...| |::|::..|.
Mouse   539 ICWVAI-SPLFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSVICIPI-YIIYRLISTP 601

  Fly   596 GDWRQRLQQCLAP 608
            |..::|:.:.:.|
Mouse   602 GTLKERIIKSITP 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13796	NP_609140.2	SLC5-6-like_sbd	123..610	CDD:444915	137/530 (26%)
Slc6a4	NP_034614.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		14/68 (21%)
		5HT_transport_N	24..64	CDD:397524	9/51 (18%)
		SLC6sbd_SERT	79..615	CDD:271399	146/577 (25%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624