DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13796 and slc6a14

DIOPT Version :9

Sequence 1:	NP_001137807.1	Gene:	CG13796 / 34051	FlyBaseID:	FBgn0031939	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001313379.1	Gene:	slc6a14 / 100150665	ZFINID:	ZDB-GENE-130411-2	Length:	614	Species:	Danio rerio

Alignment Length:	589	Identity:	149/589 - (25%)
Similarity:	253/589 - (42%)	Gaps:	80/589 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 DTLERPYRHDK--CRGRWAKSADFYFASCTHA--------FSSLIFSELSTFGILHGGWLLFIIA 126
            |..|...::|:  .||.|:...::..:...:|        |..|.:.        |||. .|:|.
Zfish    28 DKAEHVVQNDENSDRGNWSSKREYMLSMIGYAVGLGNVWRFPYLAYK--------HGGG-AFLIP 83

  Fly   127 YLMGMLFYSLPIFLIQAFLGQFSSSGTISAFRVAPIFKGIGYAILLLNLGTLTYYSIAAVVPLIY 191
            |.:.:....||:|.:::..|||.|.|.|:.::..||.:|:|..::|::.....||::.....:.|
Zfish    84 YTIMLAVSGLPLFFMESSFGQFCSQGPINVWKAVPILQGVGITMMLVSTFVAIYYNVIIAYSIYY 148

  Fly   192 TVNSIHPVIPW--MSCNNSWNTQECSLHENYDVDDYRVDPHSTVEFFRSMIASTAKGSTSMS--- 251
            ...|....:||  .:||.:.:....:.   .:|...::...|..|.:...:|  .:.|:||.
Zfish   149 LFASFQDPLPWSIKNCNTTASNISTAA---VNVSCGQISGQSLSEKYWDEVA--LQRSSSMDETG 208

  Fly   252 -ISWSMLIGVLSIWLVVLALLLKPVAFIGKVLRCSCVLMFGFFVAVFLY----LLIHEQVTF--- 308
             :.|.:.:.:|..|::|.|.|.|.:...|||:         :|.|.|.|    :|:....|.
Zfish   209 PVVWHLALCLLLSWILVGAALFKGIKSSGKVV---------YFTATFPYIVLLILLIRGATLEGA 264

  Fly   309 -DTLHYYWMPQLDSFDSI--LATA---RTALLMAGGALGPGWGSIITLSSYNNFRRDAERLSIWV 367
             |.:.:|    :.|..::  ||.|   :.|......:|...||.::.|||||.|..:..:.||.|
Zfish   265 KDGIEFY----IGSQSNLTKLAEAEVWKDAATQIFFSLSIAWGGLMALSSYNKFYNNCYQDSIVV 325

  Fly   368 CLTHITIGLMGLLCCNVAHDHFEDHVGMMPLHVDEKHHMQFLYLCFSYLFGRFTTTPNLWAFLFF 432
            |:|:....:...........|.. ||...|:...........::.:.....:...:| ||:.|||
Zfish   326 CVTNCGTSIFAGFAIFSVLGHMA-HVYQRPVSEVADAGFALAFIAYPDALSKLPISP-LWSILFF 388

  Fly   433 GMIFLSELCALIIQMMSVITALFDEF-ETLRSRRILVISSLVFCLTASSVYFCTQLGFSQLTQLP 496
            .|:....|.:....:..:.|.|.|.: |.|:|:|.||.:::...|....:...|:.|...:..:.
Zfish   389 FMLITLGLDSQFAGIEVISTCLLDAYPEVLKSKRGLVTTAVCIILFLLGLPCVTRAGIYWVNLID 453

  Fly   497 NLAVFTHLLISGIL-VLMTTWVYGRVRFQCDLQFMLGKTISSFKI------FFIRFATPIFLGLC 554
            ..:....||::|:| ||....:||..||..|::.|:|...|.|.:      |||   ||:.|.:.
Zfish   454 TFSAGWILLVAGLLEVLGLCILYGGNRFIKDIEMMIGTKSSLFWLWWRACWFFI---TPVVLSII 515

  Fly   555 LFQLTYLFTRDRIHDVLIYVSQGLIL---LTAISYM------VYKVCRTNGDWRQRLQQCLAP-H 609
            |....|.||......| .|...|:.|   :||.|.|      |:|||:..|...||::...:| .
Zfish   516 LIWSLYTFTSPTYSSV-AYPDWGISLGWCITAFSLMWIPIVAVWKVCKARGGLWQRIKSACSPTE 579

  Fly   610 DWHP 613
            ||.|
Zfish   580 DWGP 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13796	NP_001137807.1	SLC5-6-like_sbd	123..610	CDD:294310	134/523 (26%)
slc6a14	NP_001313379.1	SLC6sbd_ATB0	42..612	CDD:271391	146/575 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820