Protein Alignment CG13795 and SLC6A6

DIOPT Version :10

• Sequence 1: NP_609138.3
• Gene: CG13795 / 34049
• FlyBaseID: FBgn0031937
• Length: 594
• Species: Drosophila melanogaster
• Sequence 2: NP_001127839.2
• Gene: SLC6A6 / 6533
• HGNCID: 11052
• Length: 721
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 142/608 - (23%)
• Similarity: 258/608 - (42%)
• Gaps: 70/608 - (11%)

  Fly    20 RGKWDKPTDFMFACFGLALKL-DVFVASFWMFFDMGILGILPYFVYMSIYLVPIMVIHSFMGQFS 83
            |.||....||:.:..|..:.| :|:...:..:.:.|...::|||:::....:|:..:...:||::
Human   142 REKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYT 206

  Fly    84 SSGFISAF-RLSPFFKGMGYVSGFLTISMLIYYSIFAAVPLLFIINSFRPTLPWS-CEGLSSWHN 146
            |.|.|:.: ::.|.|.|:||.|..:...:.:||.:..|....::..||:..|||: |.  .||
Human   207 SEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCN--HSW-- 267

  Fly   147 GSATLSSSCNKTLILEDFSEYNRSHQL------LHVPSVLYFQNHYDSMQQDAVPDWYKDYELSW 205
                     |....:||....|:|..:      ...|.:.:::.:..|:.    |.......|.|
Human   268 ---------NTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLS----PGIDHPGSLKW 319

  Fly   206 HFVGLFAIIWVVIAFIFYKFSETAKFGKLIRYMVIVTLVLLLVCFVRFLFLPGALNGLHRYVTP- 269
            .......::|:|..|..:|...:.  ||::.:.......:|||..||.|.||||..|:..|:.|
Human   320 DLALCLLLVWLVCFFCIWKGVRST--GKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPD 382

  Fly   270 --KASDMAMGVVSTFIMVLHAFGAGWGSVITLSSFNGFK----TDIMSYSWIISFGQIFI--YIM 326
              :..|..:. :.....:..::....|::.:|.|:|.:|    .|.|....:.| |..|:  :.:
Human   383 ITRLEDPQVW-IDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNS-GTSFVSGFAI 445

  Fly   327 FGMVSFMLEHYFNELSDVDDNGHVLSHWLLYLSSASALSTMAWPNLWTFIYYSMLLIAALIVMTT 391
            |.::.||.:....:::||.::|..|:    :::...|::.|..|..|:.:::.|||:..|.....
Human   446 FSILGFMAQEQGVDIADVAESGPGLA----FIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFV 506

  Fly   392 QI---FTVLQSLFDEFEVLRVRK---QEVTFGLIGGIA-LCSFYFCTNHGIIFFSALGLDAIFSH 449
            ::   .|.|..|:..|    :||   :|:....:..|: |......|..|:..|......|....
Human   507 EVEGQITSLVDLYPSF----LRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGV 567

  Fly   450 SLLHLLLL--LVVLWIYGRERFQRDIEFMLGQPFASWKVFILRFIAPIILVICLLAGIALSISEH 512
            .||.:...  .|:.||||.:.....||.|:|.....|..:....|.|::.|.|.:..:...: ..
Human   568 CLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYV-PL 631

  Fly   513 SYSTTVVFV-----MSIVLVVLPILAIPGYGFYYLYQSTGTFCERFKRTCRPTD---WYPVEMEH 569
            :|:.|.|:.     :...|.:..:|.:|......|.|:.|.|..|.|....|.:   | .||.|.
Human   632 TYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPNRW-AVEREG 695

  Fly   570 RQQY-EEAVDN---TEMTHQLFE 588
            ...| ...|.|   .:.||.:.|
Human   696 ATPYNSRTVMNGALVKPTHIIVE 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13795	NP_609138.3	SLC5-6-like_sbd	27..505	CDD:271356	116/504 (23%)
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	131/570 (23%)