Protein Alignment CG13795 and Slc6a3

DIOPT Version :10

• Sequence 1: NP_609138.3
• Gene: CG13795 / 34049
• FlyBaseID: FBgn0031937
• Length: 594
• Species: Drosophila melanogaster
• Sequence 2: NP_036826.1
• Gene: Slc6a3 / 24898
• RGDID: 3715
• Length: 619
• Species: Rattus norvegicus
• Alignment Length: 592
• Identity: 138/592 - (23%)
• Similarity: 256/592 - (43%)
• Gaps: 72/592 - (12%)

  Fly    20 RGKWDKPTDFMFACFGLALKLDVFVASFWMF-----FDMGILGILPYFVYMSIYLVPIMVIHSFM 79
            |..|.|..||:.:..|.|:.|    |:.|.|     .:.|...::||.::|.|..:|:..:...:
  Rat    60 RETWSKKIDFLLSVIGFAVDL----ANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL 120

  Fly    80 GQFSSSGFISAFRLSPFFKGMGYVSGFLTISMLIYYSIFAAVPLLFIINSFRPTLPW-SCEGLSS 143
            |||:..|....:::.|..||:|:....::..:..:|::..|..|.:..:||...||| .|.  ::
  Rat   121 GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCN--NT 183

  Fly   144 WH--NGSATLSSSCNKTLILED-FSEYNRSHQLLHVPSVLYFQN-----HYDSMQQDAVPDWYKD 200
            |:  |.|...:|:.:..|.|.| |..         .|:..||:.     |......|..|.
  Rat   184 WNSPNCSDAHASNSSDGLGLNDTFGT---------TPAAEYFERGVLHLHQSRGIDDLGPP---- 235

  Fly   201 YELSWHFVGLFAIIWVVIAFIFYKFSETAKFGKLIRYMVIVTLVLLLVCFVRFLFLPGALNGLHR 265
               .|.......::.|::.|..:|..:|:  ||::.....:..|:|....:|.:.||||::|:..
  Rat   236 ---RWQLTACLVLVIVLLYFSLWKGVKTS--GKVVWITATMPYVVLTALLLRGVTLPGAMDGIRA 295

  Fly   266 YVTPKASDM--AMGVVSTFIMVLHAFGAGWGSVITLSSFNGFKTD-------IMSYSWIISFGQI 321
            |::.....:  |...:.....|..:.|.|:|.:|..||:|.|..:       ..|.:.:.||...
  Rat   296 YLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG 360

  Fly   322 FIYIMFGMVSFMLEHYFNELSDVDDNGHVLSHWLLYLSSASALSTMAWPNLWTFIYYSMLLIAAL 386
            |  ::|..:.:|.:.:...:.||..:|    ..|:::....|::|:...:.|..:::.|||...:
  Rat   361 F--VVFSFLGYMAQKHNVPIRDVATDG----PGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGI 419

  Fly   387 IVMTTQIFTVLQSLFDEFEVLRVRKQEVTFGLIGGIALCSFYFCTNHGIIFFSALGLDAIFSHSL 451
            ......:.:|:..|.|||::|...::..|.|::....|.|.:..||.||..|:.|...|..:..|
  Rat   420 DSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSIL 484

  Fly   452 LHLLLLLV-VLWIYGRERFQRDIEFMLGQ-PFASWKVFILRFIAPIILVICLLAGIALSISEHSY 514
            ..:|:..: |.|.||.::|..||:.|.|| |...|:: ..:.::|..|:..::..|......| |
  Rat   485 FGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRL-CWKLVSPCFLLYVVVVSIVTFRPPH-Y 547

  Fly   515 STTV----VFVMSIVLVVLPILAIPGYGFYYLYQSTGTFCERFKRTCRPTDWYPVEMEHRQQYEE 575
            ...:    ...:..::....:..:|.|..|......|:|.|:......|      |.:|     :
  Rat   548 GAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITP------EKDH-----Q 601

  Fly   576 AVDNTEM 582
            .||..|:
  Rat   602 LVDRGEV 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13795	NP_609138.3	SLC5-6-like_sbd	27..505	CDD:271356	120/502 (24%)
Slc6a3	NP_036826.1	SLC6sbd_DAT1	60..613	CDD:212083	138/592 (23%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		5/28 (18%)