DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13793 and Slc6a11

DIOPT Version :9

Sequence 1:	NP_609136.2	Gene:	CG13793 / 34047	FlyBaseID:	FBgn0031935	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_077348.1	Gene:	Slc6a11 / 79213	RGDID:	628737	Length:	627	Species:	Rattus norvegicus

Alignment Length:	585	Identity:	127/585 - (21%)
Similarity:	258/585 - (44%)	Gaps:	66/585 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RGNWEKPTDYIFACFGLALKL-DIFVASFWFFFNTGIFGMVPYLMYMVIYLVPIMVIHSYMGQFS 75
            ||:|....:::.:..|..:.| :::...:..:.|.|...::||:::.:...:|:..:.:.:|||:
  Rat    45 RGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFT 109

  Fly    76 SSGFISAF-RLSPLFKGMGYVSLFLTITLLIYYTIFAAVPLLFVLNSFRPTLPWSCEGFKSWQND 139
            |.|.|:.: |:.|||:|:||.:..:...|.:||.|..|..:.::.|.|...|||:..|.: |..:
  Rat   110 SEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHE-WNTE 173

  Fly   140 TIAKWSICNATIAEEVAKETENDTYFYITNIHVPSVLYFKSHFESFQNDSELNDYEISWHLSGLF 204
            ...::...|.:          |.::..:.|...|.:.:::....:..:..| :...:.|.|:...
  Rat   174 KCVEFQKLNFS----------NYSHVSLQNATSPVMEFWERRVLAISDGIE-HIGNLRWELALCL 227

  Fly   205 ALVWATIAFIFYKFSEPAKFGKCIRYMVIGTVALLLVCFVRFLFLPGAHLGLKNYMTPSIEEFV- 268
            ...|....|..:|.::..  ||.:.........:||:..:|.:.||||..|:|.|:.|.:....
  Rat   228 LAAWTICYFCIWKGTKST--GKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSD 290

  Fly   269 ------VGTSSTFIMALQAFGAGWGSVITLSSFNGFKTN-----IMSYSWIISFGQIFI--YIMF 320
                  .||...|..|:..     |.:..|.|:|.:..|     ||  ...::.|..|:  :.:|
  Rat   291 PQVWVDAGTQIFFSYAICL-----GCLTALGSYNNYNNNCYRDCIM--LCCLNSGTSFVAGFAIF 348

  Fly   321 GMVSFMLEHYFLGLPKPLFETQVINHWVLFLSSASALSSLGWPNLWTFIYYTMLLMAALIVITTQ 385
            .::.||.  |..|:  |:.|.......:.|::...|::.:....||..:::.||:...|......
  Rat   349 SVLGFMA--YEQGV--PIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVC 409

  Fly   386 IFTILQSLFDEFEQL--RAKKQEVTLGLIGGLAVCS----LYFCTNHGVLYFAILSIDAIFSQTL 444
            :.:::.::.|.:.::  |..::|:   ||..|::.|    |...|..|:..|.:....|.....|
  Rat   410 VESLVTAVVDMYPKVFRRGYRREL---LILALSIVSYFLGLVMLTEGGMYIFQLFDSYAASGMCL 471

  Fly   445 LHLLLL--LVVLWVYGRDRFQKDIKFMLG-QPFA----SWKVFILRFVAP---PTLVICLVLEIK 499
            |.:.:.  :.:.||||.:||..:|:.|:| :|.:    .|||     |.|   ..:.|..:::.|
  Rat   472 LFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKV-----VTPGICAGIFIFFLVKYK 531

  Fly   500 MCLEEHSYSSSVLHFMAIILVGL-PILAIPAYGFYYIHQRPGSISELFRATDWYPVEMEYRQQYG 563
            .....:.|:.....:....|:.| .:|.||.:.|..:.:..|::.|..:.......:::.|.:.|
  Rat   532 PLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLG 596

Fly 564 563
Rat 597 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13793	NP_609136.2	SLC5-6-like_sbd	19..498	CDD:271356	112/510 (22%)
Slc6a11	NP_077348.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
Slc6a11	NP_077348.1	SLC6sbd_GAT3	44..585	CDD:212077	125/572 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000