DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13793 and SLC6A12

DIOPT Version :9

Sequence 1:	NP_609136.2	Gene:	CG13793 / 34047	FlyBaseID:	FBgn0031935	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001116319.1	Gene:	SLC6A12 / 6539	HGNCID:	11045	Length:	614	Species:	Homo sapiens

Alignment Length:	534	Identity:	122/534 - (22%)
Similarity:	227/534 - (42%)	Gaps:	84/534 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NRGNWEKPTDYIFACFGLALKL-DIFVASFWFFFNTGIFGMVPYLMYMVIYLVPIMVIHSYMGQF 74
            :||.|....:::.:..|..:.| :::...:..:.|.|....:||.::..:..:|:..:...:||:
Human    35 DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQY 99

  Fly    75 SSSGFISAFR-LSPLFKGMGYVSLFLTITLLIYYTIFAAVPLLFVLNSFRPTLPW-SCEGFKSWQ 137
            :|.|.::|:| :.|||:|:|..|:.:...|.:||.|..|..|.::.:||...||| :|..|
Human   100 TSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNF---- 160

  Fly   138 NDTIAKWSICNATIAEEVAKETENDTYFYITNIHVPSVLYFKSHFESFQN-------------DS 189
                  |:             ||:.|.| :.:....:|    :.||:|.:             .|
Human   161 ------WN-------------TEHCTDF-LNHSGAGTV----TPFENFTSPVMEFWERRVLGITS 201

  Fly   190 ELNDY-EISWHLSGLFALVWATIAFIFYKFSEPAKFGKCIRYMVIGTVALLLVCFVRFLFLPGAH 253
            .::|. .:.|.|:....|.|....|..:|..:..  ||.:.:.......:|::..:|.:.||||:
Human   202 GIHDLGSLRWELALCLLLAWVICYFCIWKGVKST--GKVVYFTATFPYLMLVILLIRGVTLPGAY 264

  Fly   254 LGLKNYMTPSIEEFV-------VGTSSTFIMALQAFGAGWGSVITLSSFNGFKTNIMSYSWIISF 311
            .|:..|:.|.:....       .||...|     :|....|.:..|.|:|.:..|.......:.|
Human   265 QGIIYYLKPDLFRLKDPQVWMDAGTQIFF-----SFAICQGCLTALGSYNKYHNNCYKDCIALCF 324

  Fly   312 ---GQIFI--YIMFGMVSFMLEHYFLGLPKPLFETQVINHWVLFLSSASALSSLGWPNLWTFIYY 371
               ...|:  :::|.::.||.:...:    |:.|.......:.|::...|::.:....||:.:::
Human   325 LNSATSFVAGFVVFSILGFMSQEQGV----PISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFF 385

  Fly   372 TMLLMAALIVITTQIFTILQSLFDEF-EQLR-AKKQEVTLGLIGGLA-VCSLYFCTNHGVLYFAI 433
            .||:...|......:..::.:..|.| .||| :.::|:.:..|..:. :..|:..|..|:..|.:
Human   386 IMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQL 450

  Fly   434 LSIDAIFSQTLLHLLLLLVVL--WVYGRDRFQKDIKFMLGQPFASWKVFILRFVAPPTLVICLVL 496
            ....|.....||.|.|..||.  ||||.|||..:|:.|:|  :..|         |...:..|.|
Human   451 FDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIG--YRPW---------PLVKISWLFL 504

  Fly   497 EIKMCLEEHSYSSS 510
            ...:||....:|.|
Human   505 TPGLCLATFLFSLS 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13793	NP_609136.2	SLC5-6-like_sbd	19..498	CDD:271356	115/512 (22%)
SLC6A12	NP_001116319.1	SLC6sbd_BGT1	35..575	CDD:212080	122/534 (23%)
SLC6A12	NP_001116319.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	576..614
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910