Protein Alignment CG13793 and SLC6A3

DIOPT Version :10

• Sequence 1: NP_609136.2
• Gene: CG13793 / 34047
• FlyBaseID: FBgn0031935
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 146/595 - (24%)
• Similarity: 268/595 - (45%)
• Gaps: 78/595 - (13%)

  Fly    11 NRGNWEKPTDYIFACFGLALKLDIFVASFWFF-----FNTGIFGMVPYLMYMVIYLVPIMVIHSY 70
            :|..|.|..|::.:..|.|:.|    |:.|.|     .|.|...:||||::|||..:|:..:...
Human    59 DRETWGKKIDFLLSVIGFAVDL----ANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELA 119

  Fly    71 MGQFSSSGFISAFRLSPLFKGMGYVSLFLTITLLIYYTIFAAVPLLFVLNSFRPTLPW-SCEGFK 134
            :|||:..|....:::.|:.||:|:..:.:::.:..:|.:..|..|.::.:||...||| .|.  .
Human   120 LGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCN--N 182

  Fly   135 SWQNDTIAKWSICNATIAEEVAKETE--NDTYFYITNIHVPSVLYFKS---HFESFQNDSELNDY 194
            ||.:..      |:.....:.:.::.  |||:.     ..|:..||:.   |........:|...
Human   183 SWNSPN------CSDAHPGDSSGDSSGLNDTFG-----TTPAAEYFERGVLHLHQSHGIDDLGPP 236

  Fly   195 EISWHLSGLFALVWATIAFIFYKFSEPAKFGKCI------RYMVIGTVALLLVCFVRFLFLPGAH 253
            .  |.|:....||...:.|..:|..:.:  ||.:      .|:|:  .||||    |.:.||||.
Human   237 R--WQLTACLVLVIVLLYFSLWKGVKTS--GKVVWITATMPYVVL--TALLL----RGVTLPGAI 291

  Fly   254 LGLKNYMTPSIEEFVVGTSSTFIMALQ----AFGAGWGSVITLSSFNGFKTN-------IMSYSW 307
            .|::.|:  |::.:.:..:|.:|.|..    :.|.|:|.:|..||:|.|..|       ..|.:.
Human   292 DGIRAYL--SVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINS 354

  Fly   308 IISFGQIFIYIMFGMVSFMLEHYFLGLPKPLFETQVINHWVLFLSSASALSSLGWPNLWTFIYYT 372
            :.||...|  ::|..:.:|.:.:.:    |:.:.......::|:....|:::|...:.|..:::.
Human   355 LTSFSSGF--VVFSFLGYMAQKHSV----PIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFI 413

  Fly   373 MLLMAALIVITTQIFTILQSLFDEFEQLRAKKQEVTLGLIGGLAVCSLYFCTNHGVLYFAILSID 437
            |||...:......:.:::..|.|||:.|...::..||.::....:.||:..||.|:..|.:|...
Human   414 MLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHF 478

  Fly   438 AIFSQTLLHLLLLLV-VLWVYGRDRFQKDIKFMLGQ-PFASWKVFILRFVAPPTLVICLVLEIKM 500
            |..:..|..:|:..: |.|.||..:|..||:.|.|| |...|:: ..:.|:|..|:..:|:.|..
Human   479 AAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRL-CWKLVSPCFLLFVVVVSIVT 542

  Fly   501 CLEEHSYSSSVL----HFMAIILVGLPILAIPAYGFYYIHQRPGSISELFRATDWYPVEMEYRQQ 561
            ....| |.:.:.    :.:..::....:..:|.|..|.....|||    ||....|.:..|..:
Human   543 FRPPH-YGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGS----FREKLAYAIAPEKDR- 601

  Fly   562 YGELVQKSEM 571
              |||.:.|:
Human   602 --ELVDRGEV 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13793	NP_609136.2	SLC5-6-like_sbd	19..498	CDD:271356	126/508 (25%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	146/594 (25%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		8/32 (25%)