Protein Alignment CG13793 and SLC6A1

DIOPT Version :9

• Sequence 1: NP_609136.2
• Gene: CG13793 / 34047
• FlyBaseID: FBgn0031935
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001335179.1
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 145/597 - (24%)
• Similarity: 260/597 - (43%)
• Gaps: 97/597 - (16%)

  Fly     8 PDLNRGNWEKPTDYIFACFGLALKLDIFVASFWFF-----FNTGIFGMVPYLMYMVIYLVPIMVI 67
            ||  |..|:...|::.:|.|.|:.|    .:.|.|     .|.|...::||.:.::...||:.::
Human    42 PD--RDTWKGRFDFLMSCVGYAIGL----GNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLL 100

  Fly    68 HSYMGQFSSSGFISAFRLSPLFKGMGYVSLFLTITLLIYYTIFAAVPLLFVLNSFRPTLPW-SCE 131
            ...:||::|.|.:..::|:|:|||:|..:..|:..|.|||.:..:..:.::.|||..|||| .|:
Human   101 ECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCD 165

  Fly   132 GFKSWQND-TIAKWSICNATIAEEVAKETENDTYFYITNIHVPSVLYFKSHFESFQNDSELNDYE 195
              ..|..| ..:.:|:.|.|.......|      |:..|:|.             ..|......:
Human   166 --NPWNTDRCFSNYSMVNTTNMTSAVVE------FWERNMHQ-------------MTDGLDKPGQ 209

  Fly   196 ISWHLSGLFALVWATIAFIFYKFSEPAKFGKCIRYMVIGTVALLLVCFVRFLFLPGAHLGLKNYM 260
            |.|.|:...|:.|..:.|..:|  .....||.:.:.......:|::.|.|.:.||||..|:..|:
Human   210 IRWPLAITLAIAWILVYFCIWK--GVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYI 272

  Fly   261 TPSIEEFVVGTSSTFIMALQ----AFGAGWGSVITLSSFNGFKTNIMSYSWII----SFGQIFI- 316
            ||:..:  :..|..::.|..    ::|.|.||:|.|.|:|.|..|:...|.|:    |...:|.
Human   273 TPNFRK--LSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAG 335

  Fly   317 YIMFGMVSFMLEHYFLGLPKPLFETQVINHWVLFLSSASALSSLGWPNLWTFIYYTMLLMAALIV 381
            :::|.:|.|| .|.   ..:.:.:.......:.||:...|::.|....||..::::||||   :.
Human   336 FVIFSIVGFM-AHV---TKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLM---LG 393

  Fly   382 ITTQIFTI---LQSLFDEFEQLRAKKQEVTLGLIGGLAVCSLYF------CTNHGVLYFAILSID 437
            |.:|..|:   :.:|.||:.:|...::|:.:.     |||.:.:      .|..|:..|.:....
Human   394 IDSQFCTVEGFITALVDEYPRLLRNRRELFIA-----AVCIISYLIGLSNITQGGIYVFKLFDYY 453

  Fly   438 AIFSQTLLHLLLL--LVVLWVYGRDRFQKDIKFMLG-QPFASWKV---FILRFVAPPTLVICLVL 496
            :....:||.|:..  :.:.|.||.:||..:|:.|:| :|...||:   |....:.....:...|.
Human   454 SASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQ 518

  Fly   497 EIKMCLEEH---SYSSSVLHFMAIILVGLPILAIPAYGFYYIHQRPGSISELFRATDWYPVEMEY 558
            ...:.:..:   .:...|...||:    ..::.||.|..|......||:
Human   519 MTPLTMGNYVFPKWGQGVGWLMAL----SSMVLIPGYMAYMFLTLKGSL---------------- 563

  Fly   559 RQQYGELVQKSE 570
            :|:...:||.||
Human   564 KQRIQVMVQPSE 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13793	NP_609136.2	SLC5-6-like_sbd	19..498	CDD:271356	127/509 (25%)
SLC6A1	NP_001335179.1	SLC6sbd_GAT1	2..599	CDD:212075	145/597 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910