DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13793 and slc6a22.2

DIOPT Version :9

Sequence 1:	NP_609136.2	Gene:	CG13793 / 34047	FlyBaseID:	FBgn0031935	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_005166102.1	Gene:	slc6a22.2 / 561024	ZFINID:	ZDB-GENE-030616-628	Length:	608	Species:	Danio rerio

Alignment Length:	584	Identity:	131/584 - (22%)
Similarity:	240/584 - (41%)	Gaps:	81/584 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKPFSPDLNRGNWEKPTDYIFACFGLALKL-DIFVASFWFFFNTGIFGMVPYLMYMVIYLVPIMV 66
            ::|..|  .|..|....:::.|..|..:.| :::...:..:.|.|....|||::::....:|:..
Zfish    21 ARPKPP--AREQWANKLEFLLAVAGHIIGLGNVWRFPYLCYKNGGGAFFVPYVLFLFTCGIPLFF 83

  Fly    67 IHSYMGQFSSSGFISAFR-LSPLFKGMGYVSLFLTITLLIYYTIFAAVPLLFVLNSFRPTLPW-S 129
            :.:.:|||:|.|.|:.:| :.|||:|:|:.|..:.:...:||.|..|...|::.:||...||| |
Zfish    84 LETSLGQFTSQGGITCWRKICPLFEGLGFGSQVVVLYTGVYYIIILAWAFLYLFSSFTSELPWAS 148

  Fly   130 CEGFKSWQNDTIAKWSICNATIAEEVAKETENDTYFYITNIHVPSVLYFKSHFESFQNDSELNDY 194
            |..:  |...:..::|..|.|      :.:.|.|...:.......:|......|...|
Zfish   149 CNNY--WNTPSCMEFSESNIT------EYSPNKTTSPVIEFWERRILGLSGGIEQIGN------- 198

  Fly   195 EISWHLSGLFALVWATIAFIFYKFSEPAKFGKCIRYMVIGTVALLLVCFVRFLFLPGAHLGLKNY 259
             :.|.|:....|.|....|..:|..:..  ||.:.:.......:|:|..||.|.||||..|:..|
Zfish   199 -VRWDLALCLLLAWIICYFCVWKGVKST--GKVVYFTATFPYLMLIVLLVRGLTLPGAINGITFY 260

  Fly   260 MTP------SIEEFVVGTSSTFIMALQAFGAGWGSVITLSSFNGFKTNIMS---YSWIISFGQIF 315
            :.|      ..:.::...|..|    .::|...|.:..|.|:|.:..|...   |..:::....|
Zfish   261 LYPDPSRLKDPQVWMDAGSQIF----YSYGVCTGVLTALGSYNKYDNNCYRDCVYLCLLNSLTSF 321

  Fly   316 I--YIMFGMVSFMLEHYFLGLPKPLFETQVINHWVLFLSSASALSSLGWPNLWTFIYYTMLLMAA 378
            :  :.:|.::.||.:..  |:...|....  ...:.|::...|::.:..|.||...::.|::...
Zfish   322 VAGFAIFSVLGFMADEQ--GVDISLVAES--GPGLAFIAYPRAVALMPLPQLWAIFFFIMIIFLG 382

  Fly   379 L---IVITTQIFTILQSLFDEFEQLRAKKQEVTLGLIGGLAVCSLYFCTNHGVLYFAILSIDAIF 440
            |   .|....:.|.:..::..|.|:..:::.:.|.:........|...|..|:..|.:....|..
Zfish   383 LDSEFVYQEALVTSISDMYPSFFQVGHRRKFLLLFICSASFFVGLLMVTEGGLYVFQLFDYYACS 447

  Fly   441 SQTLLHLLLL--LVVLWVYGRDRFQKDIKFMLGQ---PF--ASWKVFILRFVAPPTLVICLVLEI 498
            ..|||...:|  :.|.||||.||....::.|:|.   ||  ..|| ::...:...|.:..||...
Zfish   448 GMTLLTFAILQSICVGWVYGADRHYDCVEDMIGYRPWPFMKCCWK-YLTPAICTGTFIFSLVQYT 511

  Fly   499 KMCL-EEHSY-------------SSSVLHFMAIILVGLPILAIPAYGFYYIHQRPGSISELFRA 548
            .:.. .|:.|             ||::|              :|.:..|.:...|||:.:..||
Zfish   512 PLKFNNEYEYPWWGYAIGGFFTLSSTLL--------------VPLWMIYLVGTTPGSMRQRVRA 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13793	NP_609136.2	SLC5-6-like_sbd	19..498	CDD:271356	115/502 (23%)
slc6a22.2	XP_005166102.1	SLC6sbd-TauT-like	28..565	CDD:271387	129/575 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000