DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13793 and Slc6a8

DIOPT Version :9

Sequence 1:	NP_609136.2	Gene:	CG13793 / 34047	FlyBaseID:	FBgn0031935	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_059044.1	Gene:	Slc6a8 / 50690	RGDID:	619711	Length:	635	Species:	Rattus norvegicus

Alignment Length:	603	Identity:	138/603 - (22%)
Similarity:	245/603 - (40%)	Gaps:	123/603 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RGNWEKPTDYIFACFGLALKL-DIFVASFWFFFNTGIFGMVPYLMYMVIYLVPIMVIHSYMGQFS 75
            |..|.:..|:|.:|.|.|:.| :::...:..:.|.|...::||::..::..:||..:...:|||.
  Rat    52 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFM 116

  Fly    76 SSGFISAFRLSPLFKGMGYVSLFLTITLLIYYTIFAAVPLLFVLNSFRPTLPWSCEGFKSW---- 136
            .:|.|:.:.:.|||||:||.|:.:......||.:..|....:::.||..||||:..| .:|
  Rat   117 KAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCG-HTWNTPD 180

  Fly   137 -----QNDTIAKWSICNAT---IAEE---VAKETENDTYFYITNIHVPSVLYFKSHFESFQNDSE 190
                 :::..|..|:.|.|   :|:.   |.:..||......|.:.||..|
  Rat   181 CVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSTGLEVPGAL-------------- 231

  Fly   191 LNDYEISWHLSGLFALVWATIAFIFYKFSEPAKFGKCIRYMVIGTVALLLVCFVRFLFLPGAHLG 255
                  :|.::......|..:.|..:|..:..  ||.:.:.......:|:|..||.:.||||..|
  Rat   232 ------NWEVTLCLLACWVLVYFCVWKGVKST--GKIVYFTATFPYVVLVVLLVRGVLLPGALDG 288

  Fly   256 LKNYMTPSIEEFVVGTSSTFIMA----LQAFGAGWGSVITLSSFNGFKTNIMSYSWI---ISFGQ 313
            :..|:.|...:  :|:...:|.|    ..::..|.|::..|.|:|.|..|....:.|   |:.|.
  Rat   289 IIYYLKPDWSK--LGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGT 351

  Fly   314 IFI--YIMFGMVSFMLEHYFLGLPKPLFETQVINHWVLFLSSASALSSLGWPN---------LWT 367
            .|.  :::|.::.||.....:.:.|             ...|...|:.:.:|.         ||.
  Rat   352 SFFAGFVVFSILGFMATEQGVHISK-------------VAESGPGLAFIAYPRAVTLMPVAPLWA 403

  Fly   368 FIYYTMLLMAALI--------VITTQIFTILQSLFDEFEQLRAKKQEVTLGLIGGLA-VCSLYFC 423
            .:::.|||:..|.        .||..:..:..|.:..|:      :|:::.|...|. |..|...
  Rat   404 ALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQ------REISVALCCALCFVIDLSMV 462

  Fly   424 TNHGVLYFAILSIDAIFSQTLLHLLL--LLVVLWVYGRDRFQKDIKFMLGQPFASWKVFILRFVA 486
            |:.|:..|.:....:....|||....  .:||.||||.|||..||..|:|.....|..:...|..
  Rat   463 TDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFT 527

  Fly   487 PPTLVICL------VLEIKMCLEEHSY---------------SSSV---LHFMAIILVGLPILA- 526
            |   ::|:      |:..|..:..::|               ||.:   ||.:..:|.....:|
  Rat   528 P---LVCMGIFIFNVVYYKPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAE 589

  Fly   527 ------IPAYGFYYIHQR 538
                  .|.:|.:::..|
  Rat   590 RWQHLTQPIWGLHHLEYR 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13793	NP_609136.2	SLC5-6-like_sbd	19..498	CDD:271356	125/529 (24%)
Slc6a8	NP_059044.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
Slc6a8	NP_059044.1	SLC6sbd_CT1	52..621	CDD:271397	138/603 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100