Protein Alignment CG13793 and Slc6a3

DIOPT Version :10

• Sequence 1: NP_609136.2
• Gene: CG13793 / 34047
• FlyBaseID: FBgn0031935
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_036826.1
• Gene: Slc6a3 / 24898
• RGDID: 3715
• Length: 619
• Species: Rattus norvegicus
• Alignment Length: 605
• Identity: 153/605 - (25%)
• Similarity: 268/605 - (44%)
• Gaps: 93/605 - (15%)

  Fly    12 RGNWEKPTDYIFACFGLALKLDIFVASFWFF-----FNTGIFGMVPYLMYMVIYLVPIMVIHSYM 71
            |..|.|..|::.:..|.|:.|    |:.|.|     .|.|...:||||::|||..:|:..:...:
  Rat    60 RETWSKKIDFLLSVIGFAVDL----ANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL 120

  Fly    72 GQFSSSGFISAFRLSPLFKGMGYVSLFLTITLLIYYTIFAAVPLLFVLNSFRPTLPW-SCEGFKS 135
            |||:..|....:::.|:.||:|:..:.::..:..:|.:..|..|.:..:||...||| .|
  Rat   121 GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC----- 180

  Fly   136 WQNDTIAKWSICNATIAEEVAKETE----NDTYFYITNIHVPSVLYFKS---HFESFQNDSELND 193
              |:|   |:..|.:.| ..:..::    |||:.     ..|:..||:.   |....:...:|..
  Rat   181 --NNT---WNSPNCSDA-HASNSSDGLGLNDTFG-----TTPAAEYFERGVLHLHQSRGIDDLGP 234

  Fly   194 YEISWHLSGLFALVWATIAFIFYKFSEPAKFGKCI------RYMVIGTVALLLVCFVRFLFLPGA 252
            ..  |.|:....||...:.|..:|..:.:  ||.:      .|:|:  .||||    |.:.||||
  Rat   235 PR--WQLTACLVLVIVLLYFSLWKGVKTS--GKVVWITATMPYVVL--TALLL----RGVTLPGA 289

  Fly   253 HLGLKNYMTPSIEEFVVGTSSTFIMALQ----AFGAGWGSVITLSSFNGFKTN-------IMSYS 306
            ..|::.|:  |::.:.:..:|.:|.|..    :.|.|:|.:|..||:|.|..|       ..|.:
  Rat   290 MDGIRAYL--SVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSIN 352

  Fly   307 WIISFGQIFIYIMFGMVSFMLEHYFLGLPKPLFETQVINHWVLFLSSASALSSLGWPNLWTFIYY 371
            .:.||...|  ::|..:.:|.:.:.:    |:.:.......::|:....|:::|...:.|..:::
  Rat   353 SLTSFSSGF--VVFSFLGYMAQKHNV----PIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFF 411

  Fly   372 TMLLMAALIVITTQIFTILQSLFDEFEQLRAKKQEVTLGLIGGLAVCSLYFCTNHGVLYFAILSI 436
            .|||...:......:.:::..|.|||:.|...::..|||::....:.||:..||.|:..|.:|..
  Rat   412 LMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDH 476

  Fly   437 DAIFSQTLLHLLLLLV-VLWVYGRDRFQKDIKFMLGQ-PFASWKVFILRFVAPPTLVICLVLEIK 499
            .|..:..|..:|:..: |.|.||..:|..|||.|.|| |...|:: ..:.|:|..|:..:|:.|.
  Rat   477 FAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRL-CWKLVSPCFLLYVVVVSIV 540

  Fly   500 MCLEEHSYSSSVL----HFMAIILVGLPILAIPAYGFYYIHQRPGSISELFRATDWYPVEMEYRQ 560
            .....| |.:.:.    :.:..|:....:..:|.|..|.....|||    ||....|.:
  Rat   541 TFRPPH-YGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGS----FREKLAYAI------ 594

  Fly   561 QYGELVQKSEMTHQLFDRTE 580
                   ..|..|||.||.|
  Rat   595 -------TPEKDHQLVDRGE 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13793	NP_609136.2	SLC5-6-like_sbd	19..498	CDD:271356	130/510 (25%)
Slc6a3	NP_036826.1	SLC6sbd_DAT1	60..613	CDD:212083	153/605 (25%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		9/32 (28%)