DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13793 and Slc6a7

DIOPT Version :9

Sequence 1:	NP_609136.2	Gene:	CG13793 / 34047	FlyBaseID:	FBgn0031935	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_446448.2	Gene:	Slc6a7 / 117100	RGDID:	620928	Length:	637	Species:	Rattus norvegicus

Alignment Length:	603	Identity:	168/603 - (27%)
Similarity:	265/603 - (43%)	Gaps:	73/603 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KPFSPDL------------------NRGNWEKPTDYIFACFGLALKLDIFVASFWFF-----FNT 45
            ||.:|||                  :||||....|::.:|.|..:.|    .:.|.|     .|.
  Rat    11 KPVTPDLLMTPSDQGDVDLDVDFAADRGNWTGKLDFLLSCIGYCVGL----GNVWRFPYRAYTNG 71

  Fly    46 GIFGMVPYLMYMVIYLVPIMVIHSYMGQFSSSGFISAFRLSPLFKGMGYVSLFLTITLLIYYTIF 110
            |...:|||.:.:.|..:|:..:...:|||||.|.::.:::||||||.|...|.:...:.|||.:.
  Rat    72 GGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMI 136

  Fly   111 AAVPLLFVLNSFRPTLPWSCEGFKSWQNDTIAKWSICNATIAEEVAKETENDTYFYITNIHVPSV 175
            .|..|.::..|....|||  |...:|.|        ....:.....|:........:::...||.
  Rat   137 IAYVLFYLFASLTSNLPW--EHCGNWWN--------TERCLEHRGPKDGNGALPLNLSSTVSPSE 191

  Fly   176 LYFKSHFESFQNDSEL-NDYEISWHLSGLFALVWATIAFIFYKFSEPAKFGKCIRYMVIGTVALL 239
            .|:..:....|....: ...||.|:|.....|.|..:.....|..:.:  ||.:.:.......:|
  Rat   192 EYWSRYVLHIQGSQGIGRPGEIRWNLCLCLLLAWVIVFLCILKGVKSS--GKVVYFTATFPYLIL 254

  Fly   240 LVCFVRFLFLPGAHLGLKNYMTPSIEEFVVGTSSTFI-MALQAF---GAGWGSVITLSSFNGFKT 300
            |:..||.:.||||..|::.|:||.....:  :|..:| .|||.|   |.|:|.::|.:|:|.|..
  Rat   255 LMLLVRGVTLPGAWKGIQFYLTPQFHHLL--SSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQ 317

  Fly   301 NIMSYSWIISFGQIFIYIMFGMVSFMLEHYF---LGLPKPLFETQVINHWVLFLSSASALSSLGW 362
            ||...::|::.|.....|:.|...|.:..|.   ||:  |:.:.......:.|:....|::.|..
  Rat   318 NIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGV--PVDQVAKAGPGLAFVVYPQAMTMLPL 380

  Fly   363 PNLWTFIYYTMLLMAALIVITTQIFTILQSLFDEFE-QLRAKKQEVTLGLIGGLAVCSLY----F 422
            ...|:|:::.|||...|......:.||:.::.|||. .||.||     .:..||...::|    .
  Rat   381 SPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKK-----AVFSGLICVAMYLMGLI 440

  Fly   423 CTNHGVLYFAILSID--AIFSQTLLHLLLLLVVLWVYGRDRFQKDIKFMLG-QPFASWKVFILRF 484
            .|..|.:|:.:|..|  |.|...::.:...|.|..|||..||.:||..||| :|...::...| |
  Rat   441 LTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWL-F 504

  Fly   485 VAPPTLVICLVLEI-KMCLEEH-SYSSSVLHFMAIILVG-LPILAIPAYGFYYIHQRPGSISELF 546
            ::|.||:..||..| |....|: ||.......:..||:| |..|.|||.....:.:..||:.|..
  Rat   505 LSPATLLALLVYSIVKYQPSEYGSYRFPAWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERL 569

  Fly   547 R-----ATDWYPVEMEYR 559
            :     |.||.|...|.|
  Rat   570 QQASRPAIDWGPSLEENR 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13793	NP_609136.2	SLC5-6-like_sbd	19..498	CDD:271356	137/499 (27%)
Slc6a7	NP_446448.2	SLC5-6-like_sbd	37..581	CDD:382020	160/569 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810