Protein Alignment Ntl and Slc6a2

DIOPT Version :9

• Sequence 1: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_112633.2
• Gene: Slc6a2 / 83511
• RGDID: 621822
• Length: 617
• Species: Rattus norvegicus
• Alignment Length: 542
• Identity: 211/542 - (38%)
• Similarity: 346/542 - (63%)
• Gaps: 14/542 - (2%)

  Fly    24 RGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEILIGQFS 88
            |..|..|.:|:||::|:|:.:.||||||||||::||.||||||.|.:|:||:||||||:.:|||:
  Rat    56 RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFN 120

  Fly    89 STGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSNSWNTDDC 153
            ..|...::::.|..||.|.|.:::..|...||:|||::.:..:|..|...:||.:|.::||:.:|
  Rat   121 REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNC 185

  Fly   154 -----VTASDMGKQNSSDVFK-TSADEFFHLEVLRI--STDISDLGGMVWEQLTALIITWIIIYF 210
                 :.||.:|.......:| |.|.||:...||.:  |:.|.|:|...|:.|..|::..:::||
  Rat   186 TDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYF 250

  Fly   211 CLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQM 275
            .|.:|:|:.||||:.|...||.:||:||:.|.|||||..||..||:.:::||.:..||.|||.|:
  Rat   251 SLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQI 315

  Fly   276 FFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESVA 340
            ||.:|.|:|.::..||::.|.||...|::|..:||..||.::||.:||:||:::.:..:.:|.||
  Rat   316 FFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVA 380

  Fly   341 TGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWVRSHKCKL 405
            |.||||.||.|||||:.|.....||::||.||..||:||....:||:::.:.|::..::.|:
  Rat   381 TEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHR--- 442

  Fly   406 TLISCLIFLG--LSSIMC-TNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEF 467
            .|.:|.:.||  |.::.| |.||:::|.|.|.:::..:::...|:|.|.|:|.||:..|..|::.
  Rat   443 KLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQ 507

  Fly   468 MLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYPQWAIIIGWASCFTSVMWIPLY 532
            |:|.:|.||||:.|:.|:|..::|:::.||:..:.:||::..||.||..:||....:|::.:|.|
  Rat   508 MMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAY 572

  Fly   533 IFYIMIRKRATLCDSLKKRLKP 554
            :.|.....|.:|.:.:...:.|
  Rat   573 VIYKFFSIRGSLWERVAYGITP 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	210/540 (39%)
Slc6a2	NP_112633.2	SLC5-6-like_sbd	56..615	CDD:382020	211/542 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820