DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and Slc6a11

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_077348.1	Gene:	Slc6a11 / 79213	RGDID:	628737	Length:	627	Species:	Rattus norvegicus

Alignment Length:	587	Identity:	239/587 - (40%)
Similarity:	354/587 - (60%)	Gaps:	27/587 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLF 78
            :||.:   ..||.|.:|.||:||:.|..||:|||||||||||::||.||||||::..|..|||:|
  Rat    38 RDKAV---HERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVF 99

  Fly    79 YMEILIGQFSST-GCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWE 142
            ::|..:|||:|. |.|...|:.||.:|.|.|..|:.|:...||.:|:::.|..:..||..::||.
  Rat   100 FLETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWA 164

  Fly   143 DCSNSWNTDDCVTASDMGKQNSSDVFKTSAD----EFFHLEVLRISTDISDLGGMVWEQLTALII 203
            .|.:.|||:.||....:...|.|.|...:|.    ||:...||.||..|..:|.:.||....|:.
  Rat   165 TCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLA 229

  Fly   204 TWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVW 268
            .|.|.|||:.:|.||.|||||.|..|||::|.||||||.|||||.:||||||||:..||.|.:||
  Rat   230 AWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVW 294

  Fly   269 ADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSG 333
            .||..|:||......|.:..:.|::::.||...|.:::..:|..||.:|||.:||||||::.:.|
  Rat   295 VDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQG 359

  Fly   334 IPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWV 398
            :|:..||..|.||||:.||:|:.::|:..|||.:||.||..||:||.||.:|:::::::|.:..|
  Rat   360 VPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKV 424

  Fly   399 --RSHKCKLTLISCLI---FLGLSSIMCTNGGMFILQLFDWY-SSAIAVIVICLVEIIMVAWIYG 457
              |.::.:|.:::..|   ||||  :|.|.|||:|.||||.| :|.:.::.:.:.|.:.:.|:||
  Rat   425 FRRGYRRELLILALSIVSYFLGL--VMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYG 487

  Fly   458 IKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNI-PYPQWAIIIGWAS 521
            ...|..::|.|:|.||....:..|:||||.|...|.|..:|..:.:.|||: .||.|...|||..
  Rat   488 SNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLM 552

  Fly   522 CFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPLDWTPADPQDRAEYEAFRRQRRMPGFMSDTDM 586
            ..:|::.|||:||..:.:...||.:.|:|...|    .||.:.|.:..|      .|..::..|.
  Rat   553 ALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVP----SADLKMRGKLGA------SPRMVTVNDC 607

  Fly   587 ES 588
            |:
  Rat   608 EA 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	229/541 (42%)
Slc6a11	NP_077348.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
Slc6a11	NP_077348.1	SLC6sbd_GAT3	44..585	CDD:212077	229/542 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820