DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ntl and Slc6a1

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_077347.1	Gene:	Slc6a1 / 79212	RGDID:	620533	Length:	599	Species:	Rattus norvegicus

Alignment Length:	582	Identity:	221/582 - (37%)
Similarity:	362/582 - (62%)	Gaps:	27/582 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PTTNATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVI 71
            |.|...:..|:.....:|..||.:.:|::|.:|||||:||||||||||.::||.||||||.|.:|
  Rat    27 PKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLI 91

  Fly    72 LAGIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFF 136
            .||:|||.:|..:||::|.|..|::::.|:.||.|:|..|::.:...||.||||:.|..::..|.
  Rat    92 FAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFT 156

  Fly   137 KKVPWEDCSNSWNTDDCVTASDMGKQNSSDVFKTSA-DEFFHLEVLRISTDISDLGGMVWEQLTA 200
            ..:||:.|.|.||||.|.  |:....|::::  ||| .||:...:.:::..:...|.:.|.....
  Rat   157 TTLPWKQCDNPWNTDRCF--SNYSLVNTTNM--TSAVVEFWERNMHQMTDGLDKPGQIRWPLAIT 217

  Fly   201 LIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDL 265
            |.|.|:::|||:.:|:...||||||:..:||::|.||..||.|||||.:||.||:.|.:.:|.|.
  Rat   218 LAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDS 282

  Fly   266 KVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSE 330
            :||.|||.|:||..|.|.|.::.:.|::||.||...||:::..||..||:.||||:||::||::.
  Rat   283 EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAH 347

  Fly   331 KSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEW 395
            .:...:..||..|.||||:.||||:..||:..|||::||.||.:|||||.|..:|..:::::||:
  Rat   348 VTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEY 412

  Fly   396 YWVRSHKCKLTLIS-CLI--FLGLSSIMCTNGGMFILQLFDWYS-SAIAVIVICLVEIIMVAWIY 456
            ..:..::.:|.:.: |::  .:|||:|  |.||:::.:|||:|| |.::::.:...|.:.::|.|
  Rat   413 PRLLRNRRELFIAAVCIVSYLIGLSNI--TQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFY 475

  Fly   457 GIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYPQWAIIIGWAS 521
            |:..|..:::.|:|.||.::|::.|...||:|:..:.:.|.|.:..:|..:..:|:|...:||..
  Rat   476 GVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLM 540

  Fly   522 CFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPL----------DWTPADPQ--DRAEYEAF 571
            ..:|::.||.|:.|:.:    ||..|||:||:.:          :..|..||  ..|..||:
  Rat   541 ALSSMVLIPGYMAYMFL----TLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAY 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	212/534 (40%)
Slc6a1	NP_077347.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		SLC6sbd_GAT1	2..599	CDD:212075	221/582 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..599		6/22 (27%)
		PDZ-binding	597..599		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820