DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ntl and slc6a1a

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001038752.2	Gene:	slc6a1a / 692318	ZFINID:	ZDB-GENE-060519-23	Length:	679	Species:	Danio rerio

Alignment Length:	587	Identity:	223/587 - (37%)
Similarity:	360/587 - (61%)	Gaps:	25/587 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANNQPPTTNATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIP 65
            :..|..|.|...:.:|..:...:|..|..|.:|:||.:|||||:||||||||||.::||.|||||
Zfish    20 ITTNDKPKTEDAKPEKNKKDIPDRETWGGKFDFLLSCVGYAIGLGNVWRFPYLCGKNGGGAFLIP 84

  Fly    66 YLLMVILAGIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRM 130
            |.|.:|.||:|||::|..:||::|.|..|::::.|:.||.|:|..|::.:...||.|||::.:..
Zfish    85 YFLTLIFAGVPLFFLECALGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIIAWALYY 149

  Fly   131 IFYCFFKKVPWEDCSNSWNTDDCVTASDMGKQNSSDVFKTSAD----EFFHLEVLRISTDISDLG 191
            ::..|...:||:.|:|.||||.|.|       |.|.|..|:..    ||:...|.:::..:...|
Zfish   150 LYNSFTTDLPWKSCNNPWNTDRCYT-------NYSIVDTTNLTSAVMEFWERNVHQMTDGLEKPG 207

  Fly   192 GMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLY 256
            .:.......|.|.|:::|||:.:|:...||||||:..:||.:||||.|||.|||||.:||.||:.
Zfish   208 EIRVPLAITLAIAWVLVYFCIWKGVSWTGKVVYFSATYPYFMLFILFIRGVTLPGAKEGILFYIT 272

  Fly   257 PEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVV 321
            |::.:|.:.:||.|||.|:||..|.|.|.::.:.|::.|.||...||:::..||.|||:.||||:
Zfish   273 PDFEKLKESEVWLDAATQIFFSYGLGLGSLIALGSYNPFNNNVYRDSIIVCCINSFTSMFAGFVI 337

  Fly   322 FSVLGFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEA 386
            ||::||:|..:..|:..||..|.||||:.||||:..|||..|||::||.||.:|||||.|..:|.
Zfish   338 FSIVGFMSHVTKRPIADVAASGPGLAFLAYPEAVTQLPVSPLWAILFFSMLLMLGIDSQFCTVEG 402

  Fly   387 IMSSILDEWYWVRSHKCKLTLISCLIF----LGLSSIMCTNGGMFILQLFDWYS-SAIAVIVICL 446
            .:::::||:..: ..|.:...|:|:..    :|||:|  |.||:::.:|||:|| |.:.::.:..
Zfish   403 FITALVDEFPRL-LRKRREIFIACVCVVSYAIGLSNI--TQGGLYVFKLFDYYSASGMCLLFLVF 464

  Fly   447 VEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYP 511
            .|.|.::|.||:..|..:::.|:|.:|.::|::.|...||:::..:.:.|.|.:..:|.||..:|
Zfish   465 FECISISWCYGVNKFYDNIQEMIGYKPCIWWKLCWVFFTPLVVAGVFLFSAVQMVPLTMNNYVFP 529

  Fly   512 QWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPLDWTPADPQDRAEYEAFRRQRR 576
            :|...:||....:|::.||.|:.|:.:..:.|..:.::..|:|    ||  ..||:.....:|:.
Zfish   530 KWGQGVGWLMALSSMVLIPGYMGYMFLNLKGTYKERIRIMLQP----PA--VKRAQENGPEQQQS 588

  Fly   577 MP 578
            .|
Zfish   589 QP 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	212/538 (39%)
slc6a1a	NP_001038752.2	SLC5-6-like_sbd	2..588	CDD:294310	222/583 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920