DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and slc6a4b

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001170930.1	Gene:	slc6a4b / 664770	ZFINID:	ZDB-GENE-060314-2	Length:	591	Species:	Danio rerio

Alignment Length:	574	Identity:	217/574 - (37%)
Similarity:	361/574 - (62%)	Gaps:	30/574 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEI 82
            |.:.|:|.:|..|.:|:||::|:|:.:||||||||:||::||.||||||:||.:..|:||||||:
Zfish    32 IIQTESRDKWSKKMDFLLSVIGFAVDLGNVWRFPYICYQNGGGAFLIPYVLMAVFGGVPLFYMEL 96

  Fly    83 LIGQFSSTGCTGMFR-MTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSN 146
            .:|||..||...::: :.|:.||.|.|..::..|...||:.||::.:...:..|...:||..|.|
Zfish    97 ALGQFHRTGAISIWKHICPIFKGIGFAICIIALYVSFYYNTIIAWALFYFYSSFSSTLPWTSCDN 161

  Fly   147 SWNTDDCVTASDMGKQNS--SDVFKTSADEFFHLEVLRI--STDISDLGGMVWEQLTALIITWII 207
            .|||::|  .:..||.|.  ::..::.|:||:...||.:  |:.:.::|.:.|:.:..|.:.:.|
Zfish   162 DWNTENC--TNYFGKDNVTWTNYSRSPAEEFYTRNVLAVHESSGLGNVGYIRWQLMLCLFLIFTI 224

  Fly   208 IYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAA 272
            :||.|.:|:|:.||||:.|...||::|.||:||||||||||||:.|||.|:|.:|.:..||.|||
Zfish   225 VYFSLWKGVKTSGKVVWVTATLPYVVLLILMIRGATLPGAWKGVVFYLNPKWEKLKETSVWVDAA 289

  Fly   273 VQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVE 337
            .|:||.:|||:|.::.::|::.|.||...|:::...:|..||.::|||:|:|||:::|:..:.||
Zfish   290 AQIFFSLGPGFGVLLALSSYNPFTNNCYRDAIVTSLVNCLTSFVSGFVIFTVLGYMAEQRNVNVE 354

  Fly   338 SVATG-GAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWVRSH 401
            .||.. |..|.|:|||||||.:.....:|::||.|:..||:||.|..||||:::::||:..|.||
Zfish   355 DVARDKGPSLLFITYPEAIANMVGSTFFAIIFFVMMITLGLDSTFGGLEAIITAVMDEYPDVLSH 419

  Fly   402 KCKLTLISCLI--FLGLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLD 464
            :.:|.::..::  |||..|.: |.||.::::|.:.:....::|.|..:|...|:|.|||..|..|
Zfish   420 RRELFVLGLVVVCFLGSLSTL-TKGGAYVVKLLEEFGVGSSIIAIVFLEATAVSWFYGINRFSND 483

  Fly   465 VEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYPQWAIIIGWASCFTSVMWI 529
            ::.|||..|.|:|::.|..::|..:.:|:|:|::..:|:|..:..:|.|:|.:|:....:|.:||
Zfish   484 IKSMLGYTPGLFWKVCWVAISPAFLAYIIISSLLNPQTLTLFDYEFPDWSITVGYIIGASSFIWI 548

  Fly   530 PLYIFYIMIRKRATLCDSLKKRLKPLDWTPADPQDRAEYEAFRRQRRMPGFMSD 583
            |:|:.|.::                  |||...:.|... ..|.:|.:|...:|
Zfish   549 PIYMVYKLV------------------WTPGSLKQRLAV-CLRPERTLPDIHTD 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	207/537 (39%)
slc6a4b	NP_001170930.1	SLC6sbd_SERT	38..574	CDD:271399	212/557 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820