Protein Alignment Ntl and SLC6A13

DIOPT Version :9

• Sequence 1: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_057699.2
• Gene: SLC6A13 / 6540
• HGNCID: 11046
• Length: 602
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 223/574 - (38%)
• Similarity: 340/574 - (59%)
• Gaps: 33/574 - (5%)

  Fly     7 PTTNATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVI 71
            |......:|..:|    ||.|.:|.||:||:.|..||:|||||||||||::||.||.||||:.:.
Human    19 PVMEKKEEDGTLE----RGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLF 79

  Fly    72 LAGIPLFYMEILIGQFSST-GCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCF 135
            ..|||:|.:|..:||::|. |.|...::.|:.:|.|.|..::......||.:::::.:..:|..|
Human    80 TCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSF 144

  Fly   136 FKKVPWEDCSNSWNTDDCVT-ASDMGKQNSSDVFKTS-ADEFFHLEVLRISTDISDLGGMVWEQL 198
            ...:||..|.:.|||:.|:. ....|..|.:....|| ..||:...||:||..|..||.:.||..
Human   145 TIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGALRWELA 209

  Fly   199 TALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLL 263
            ..|::.|:|.|||:.:|:||.|||||||..||||:|.:|||||.|||||.:||:|||||...||.
Human   210 LCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLW 274

  Fly   264 DLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFL 328
            |.:||.||..|:||......|.:..:.|::.:.||...|.:.:..:|..||.:|||.:||:|||:
Human   275 DPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFM 339

  Fly   329 SEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILD 393
            |::.|:|:..||..|.||||:.||.|:.:||...|||..||||:.|||:||.||.:|:::::::|
Human   340 SQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVD 404

  Fly   394 EWYWVRSHKCK-------LTLISCLIFLGLSSIMCTNGGMFILQLFDWY-SSAIAVIVICLVEII 450
            .:..|...|.:       ::::|.|:.|    ||.|.|||::.||||:| :|.:.::.:.:.|.:
Human   405 MYPHVFRKKNRREVLILGVSVVSFLVGL----IMLTEGGMYVFQLFDYYAASGMCLLFVAIFESL 465

  Fly   451 MVAWIYGIKNFMLDVEFMLGKRPTLYWRIV---WQVVTPVIIIFILITSIVFIRTITYN-NIPYP 511
            .|||:||.|.|..::|.|:|.||   |.::   |..:||.:.....:.|::....:||| ...||
Human   466 CVAWVYGAKRFYDNIEDMIGYRP---WPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYP 527

  Fly   512 QWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPLDWTPAD--PQ 563
            .|...:||....:|::.||.:..|    :..||....::|::.| ..||:  ||
Human   528 WWGDALGWLLALSSMVCIPAWSLY----RLGTLKGPFRERIRQL-MCPAEDLPQ 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	215/544 (40%)
SLC6A13	NP_057699.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		1/2 (50%)
		SLC6sbd_GAT2	32..575	CDD:271396	218/554 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820