Protein Alignment Ntl and SLC6A11

DIOPT Version :9

• Sequence 1: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_055044.1
• Gene: SLC6A11 / 6538
• HGNCID: 11044
• Length: 632
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 230/559 - (41%)
• Similarity: 345/559 - (61%)
• Gaps: 17/559 - (3%)

  Fly    11 ATRKDKRIERDE---NRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVIL 72
            |..:..|::||:   .||.|.:|.||:||:.|..||:|||||||||||::||.||||||::..|.
Human    34 APARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFIC 98

  Fly    73 AGIPLFYMEILIGQFSST-GCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFF 136
            .|||:|::|..:|||:|. |.|...::.||.:|.|.|..|:.|:...||.:|:::.|..:..||.
Human    99 CGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFT 163

  Fly   137 KKVPWEDCSNSWNTDDCVTASDMGKQNSSDVFKTSAD----EFFHLEVLRISTDISDLGGMVWEQ 197
            .::||..|.:.|||::||....:...|.|.|...:|.    ||:...||.||..|..:|.:.||.
Human   164 TELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWEL 228

  Fly   198 LTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRL 262
            ...|:..|.|.|||:.:|.||.|||||.|..|||::|.||||||.|||||.:||||||||:..||
Human   229 ALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRL 293

  Fly   263 LDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGF 327
            .|.:||.||..|:||......|.:..:.|::::.||...|.:::..:|..||.:|||.:||||||
Human   294 SDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGF 358

  Fly   328 LSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSIL 392
            ::.:.|:|:..||..|.||||:.||:|:.::|:..|||.:||.||..||:||.||.:|:::::::
Human   359 MAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVV 423

  Fly   393 DEWYWV--RSHKCKLTLISCLI---FLGLSSIMCTNGGMFILQLFDWY-SSAIAVIVICLVEIIM 451
            |.:..|  |.::.:|.:::..:   ||||  :|.|.|||:|.||||.| :|.:.::.:.:.|.|.
Human   424 DMYPKVFRRGYRRELLILALSVISYFLGL--VMLTEGGMYIFQLFDSYAASGMCLLFVAIFECIC 486

  Fly   452 VAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNI-PYPQWAI 515
            :.|:||...|..::|.|:|.||....:..|.::||.|...|.|..::..:.:.|||| .||.|..
Human   487 IGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGY 551

  Fly   516 IIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKP 554
            .|||....:|::.|||:|...:.:...||.:.|:|...|
Human   552 GIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTP 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	225/541 (42%)
SLC6A11	NP_055044.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		1/6 (17%)
		SLC6sbd_GAT3	49..590	CDD:212077	225/542 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820