DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ntl and SLC6A9

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_964012.2	Gene:	SLC6A9 / 6536	HGNCID:	11056	Length:	706	Species:	Homo sapiens

Alignment Length:	586	Identity:	250/586 - (42%)
Similarity:	372/586 - (63%)	Gaps:	35/586 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANNQPPTTNATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIP 65
            ||.|....:.||::|:.::    ||.|.::.||:|:.:|||:|:||||||||||||:||.||:.|
Human    81 MAQNGAVPSEATKRDQNLK----RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFP 141

  Fly    66 YLLMVILAGIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRM 130
            |.:|:|..|||||:||:..|||:|.||.|::|::|:.||.|...:||:.|...||:|:|.    :
Human   142 YFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVIC----I 202

  Fly   131 IFYCFFKK----VPWEDCSNSWNTDDCVTASDMGK-----------QNSSDVFKTS------ADE 174
            .||.||..    :||..|:|.|||.||....|...           .|.|.:...|      ::|
Human   203 AFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEE 267

  Fly   175 FFHLEVLRISTDISDLGGMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLI 239
            ::.|.||::|.||.:.|.:....|..|.::|::::.||:||:||.|||||||..|||::|.||.:
Human   268 YWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFV 332

  Fly   240 RGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSV 304
            ||.||.||:.||.:||.|:|.::|:.|||.|||.|:|:.:|..|||::.|||::.|.||...|||
Human   333 RGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSV 397

  Fly   305 LIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFF 369
            :|...|..||:.||||:||:|||::...|:.|..||..|.|||||.||||:.|||:..||:|:||
Human   398 IISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFF 462

  Fly   370 FMLFLLGIDSVFVQLEAIMSSILDEW--YWVRSHKCKLTL-ISCLIFLGLSSIMCTNGGMFILQL 431
            |||.|||:.:.|..||.::::|:||.  .|:...|..:|| ::...|| |...:.:..|::.|.|
Human   463 FMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFL-LGIPLTSQAGIYWLLL 526

  Fly   432 FDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITS 496
            .|.|:::.:::||..:..:.:.:|||.:|:..|::.|||..|.|:::|.|:.|:|.||.|||:.:
Human   527 MDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFT 591

  Fly   497 IVFIRTITYNNIPYPQWAIIIGWASCFTSVMWIPLYIFYIMIRKRA-TLCDSLKKRLKP-LDWTP 559
            ::..:.||||:..||.||:.||:....:||:.||||..:.:.|... ||...||...|| .||.|
Human   592 VIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGP 656

  Fly   560 A 560
            |
Human   657 A 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	238/554 (43%)
SLC6A9	NP_964012.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
SLC6A9	NP_964012.2	SLC6sbd_GlyT1	84..667	CDD:212067	248/583 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5050
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0009703
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6310
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820