DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and SLC6A8

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_005620.1	Gene:	SLC6A8 / 6535	HGNCID:	11055	Length:	635	Species:	Homo sapiens

Alignment Length:	556	Identity:	213/556 - (38%)
Similarity:	333/556 - (59%)	Gaps:	30/556 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEILIGQFS 88
            |..|..:.:||:|.:|:|:|:|||||||||||::||..|||||:|:.::.|||:|::||.:|||.
Human    52 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFM 116

  Fly    89 STGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSNSWNTDDC 153
            ..|...::.:.||.||.|.|.:|:..||..||.:::::....:...|...:||..|.::|||.||
Human   117 KAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDC 181

  Fly   154 V----------------TASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTALI 202
            |                |...:..:.|..:      ||:..:|||:|..:...|.:.||....|:
Human   182 VEIFRHEDCANASLANLTCDQLADRRSPVI------EFWENKVLRLSGGLEVPGALNWEVTLCLL 240

  Fly   203 ITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKV 267
            ..|:::|||:.:|:||.||:||||..|||::|.:||:||..||||..||.:||.|:|.:|...:|
Human   241 ACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQV 305

  Fly   268 WADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKS 332
            |.||..|:||....|.|.:..:.|::.|.||...|::::..||..||..|||||||:|||::.:.
Human   306 WIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQ 370

  Fly   333 GIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILD---- 393
            |:.:..||..|.||||:.||.|:.|:||..|||.:|||||.|||:||.||.:|..::.:||
Human   371 GVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPA 435

  Fly   394 EWYWVRSHKCKLTLISCLIFLGLSSIMCTNGGMFILQLFDWYS-SAIAVIVICLVEIIMVAWIYG 457
            .:|:....:..:.|...|.|: :...|.|:|||::.||||:|| |...::.....|.::|||:||
Human   436 SYYFRFQREISVALCCALCFV-IDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYG 499

  Fly   458 IKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNN-IPYPQWAIIIGWAS 521
            ...||.|:..|:|.||..:.:..|...||::.:.|.|.::|:...:.||| ..||.|...:|||.
Human   500 ADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAF 564

  Fly   522 CFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPLDW 557
            ..:|::.:||::...::|.:.|:.:..:...:|: |
Human   565 ALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPI-W 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	211/551 (38%)
SLC6A8	NP_005620.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
SLC6A8	NP_005620.1	SLC6sbd_CT1	52..621	CDD:271397	213/556 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820