DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and SLC6A7

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_016865256.1	Gene:	SLC6A7 / 6534	HGNCID:	11054	Length:	754	Species:	Homo sapiens

Alignment Length:	597	Identity:	225/597 - (37%)
Similarity:	359/597 - (60%)	Gaps:	46/597 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFY 79
            |..::...:||.|..|.:|:||.:||.:|:||||||||..|.:||.|||:||.||:.:.|||||:
Human   109 DLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFF 173

  Fly    80 MEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDC 144
            :|:.:|||||.|...:::::||.||.|.|.:::......||::||:|.:..:|......:|||.|
Human   174 LELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHC 238

  Fly   145 SNSWNTDDCV--------------------------------TASDMGKQ-----NS--SDVF-- 168
            .|.|||:.|:                                .|.:.|::     ||  ..:|
Human   239 GNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSQTHTEAEEEGRRGRVVSNSYPQVIFLP 303

  Fly   169 -KTSADEFFHLEVLRI--STDISDLGGMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFP 230
             ...|:|.....||.|  |..|...|.:.|.....|::.|:|::.|:::|:||.|||||||..||
Human   304 QPPKAEEGVSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFP 368

  Fly   231 YLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSF 295
            ||:|.:||:||.|||||||||:|||.|::|.||..|||.:||:|:|:.:|.|:||::..||:::|
Human   369 YLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTF 433

  Fly   296 RNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPV 360
            ..|...|:.::...|..||:||||.:|||||::|::.|:||:.||..|.|||||.||:|:.:||:
Human   434 HQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPL 498

  Fly   361 PQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEW-YWVRSHKCKLTLISCLIFLGLSSIMCTNG 424
            ...|:.:|||||..||:||.|..||.|::::.||: |::|..|...:.:.|:....:..|:.|:|
Human   499 SPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDG 563

  Fly   425 GMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVII 489
            ||:.|.|.|.||::..::|:.:...:.|..:|||:.|..|:..|||.:|.||:|..|..::|..:
Human   564 GMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATL 628

  Fly   490 IFILITSIVFIRTITYNNIPYPQWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKP 554
            :.:::.|||..:...|.:..:|.||.::|......|.:.||..:...::|:..:|.:.|::..:|
Human   629 LALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRP 693

  Fly   555 -LDWTPADPQDR 565
             :||.|:..::|
Human   694 AMDWGPSLEENR 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	219/574 (38%)
SLC6A7	XP_016865256.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100873
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820