DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and SLC6A6

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001127839.2	Gene:	SLC6A6 / 6533	HGNCID:	11052	Length:	721	Species:	Homo sapiens

Alignment Length:	574	Identity:	222/574 - (38%)
Similarity:	353/574 - (61%)	Gaps:	27/574 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PPTTNATRKDKRIE-RDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLM 69
            |..:..||.:...| :...|.:|.||.:|:||:.|..:|:|||||||||||::||.||||||.:.
Human   123 PGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIF 187

  Fly    70 VILAGIPLFYMEILIGQFSST-GCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFY 133
            :..:|:|:|::||:|||::|. |.|...::.||..|.|.|.||:.:....||.||:::....:|.
Human   188 LFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQ 252

  Fly   134 CFFKKVPWEDCSNSWNTDDCVTASDMGKQN-------SSDVFKTSADEFFHLEVLRISTDISDLG 191
            .|.|::||..|::||||..|:  .|..::|       ||..|.:...||:...||.:|..|...|
Human   253 SFQKELPWAHCNHSWNTPHCM--EDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPG 315

  Fly   192 GMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLY 256
            .:.|:....|::.|::.:||:.:|::|.|||||||..||:.:|.:||:||.|||||..|||||||
Human   316 SLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLY 380

  Fly   257 PEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVV 321
            |:..||.|.:||.||..|:||......|.:.::.|::.::.|:..|.:|:..:|..||.::||.:
Human   381 PDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAI 445

  Fly   322 FSVLGFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEA 386
            ||:|||::::.|:.:..||..|.||||:.||:|:.::|:|..|:::||.||.|||:||.||::|.
Human   446 FSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEG 510

  Fly   387 IMSSILDEW--YWVRSHKCKLTL-ISCLIFLGLSSIMCTNGGMFILQLFDWY-SSAIAVIVICLV 447
            .::|::|.:  :..:.::.::.: ..|.|...|...|.|.|||::.||||:| :|.:.::.:...
Human   511 QITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFF 575

  Fly   448 EIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYN-NIPYP 511
            |..::|||||..|....:|.|:|.||..:.:..|.|:|||:.:...|.|:|....:||| ...||
Human   576 ECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYP 640

  Fly   512 QWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDS---LKKRLKPLDWTPADP 562
            .|||.:||:...:|::.:||   .|:||    ||.:   ...|:|.| .||.:|
Human   641 NWAIGLGWSLALSSMLCVPL---VIVIR----LCQTEGPFLVRVKYL-LTPREP 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	213/545 (39%)
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	215/550 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820