Protein Alignment Ntl and SLC6A4

DIOPT Version :10

• Sequence 1: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_001036.1
• Gene: SLC6A4 / 6532
• HGNCID: 11050
• Length: 630
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 226/569 - (39%)
• Similarity: 351/569 - (61%)
• Gaps: 26/569 - (4%)

  Fly     6 PPTTNATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMV 70
            |.||  |.....:.:.| |..|..|.:|:||::|||:.:||||||||:||::||.|||:||.:|.
Human    64 PATT--TTLVAELHQGE-RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMA 125

  Fly    71 ILAGIPLFYMEILIGQFSSTGCTGMFR-MTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYC 134
            |..||||||||:.:||:...||..::| :.|:.||.|.|..::..|...||:.|:::.:..:...
Human   126 IFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISS 190

  Fly   135 FFKKVPWEDCSNSWNTDDCVTASDMGKQNSS-DVFKTS-ADEFFHLEVLRI--STDISDLGGMVW 195
            |..::||..|.|||||.:|  .:...:.|.: .:..|| |:||:...||:|  |..:.||||:.|
Human   191 FTDQLPWTSCKNSWNTGNC--TNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISW 253

  Fly   196 EQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWH 260
            :....:::.:.:|||.:.:|:|:.||||:.|..|||::|.:||:|||||||||:|:.|||.|.|.
Human   254 QLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQ 318

  Fly   261 RLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVL 325
            :||:..||.|||.|:||.:|||:|.::..||::.|.||...|:::...:|..||.::|||:|:||
Human   319 KLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVL 383

  Fly   326 GFLSEKSGIPVESVA-TGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMS 389
            |:::|.....|..|| ..|..|.|:||.||||.:|....:|::||.||..||:||.|..||.:::
Human   384 GYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVIT 448

  Fly   390 SILDE----WYWVRSHKCKLTLISCLIFLGLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEII 450
            ::|||    |...|.......:|:|  |.| |.:..|.||.::::|.:.|::..||:.:.|:|.:
Human   449 AVLDEFPHVWAKRRERFVLAVVITC--FFG-SLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAV 510

  Fly   451 MVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVF---IRTITYNNIPYPQ 512
            .|:|.|||..|..||:.|||..|..:|||.|..::|:.::||:.:.::.   :|...||   ||.
Human   511 AVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYN---YPY 572

  Fly   513 WAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPLDWTPAD 561
            |:||:|:....:|.:.||.||.|.:|....|..:.:.|.:.|  .||.:
Human   573 WSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITP--ETPTE 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:444915	218/542 (40%)
SLC6A4	NP_001036.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59
		5HT_transport_N	24..64	CDD:397524	226/569 (40%)
		SLC6sbd_SERT	79..615	CDD:271399	219/545 (40%)
		Interaction with RAB4A	616..624		2/4 (50%)