Protein Alignment Ntl and SLC6A3

DIOPT Version :9

• Sequence 1: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 221/559 - (39%)
• Similarity: 350/559 - (62%)
• Gaps: 13/559 - (2%)

  Fly    22 ENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEILIGQ 86
            ::|..|..|.:|:||::|:|:.:.||||||||||::||.|||:||||.:::||:||||||:.:||
Human    58 QDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQ 122

  Fly    87 FSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSNSWNTD 151
            |:..|..|::::.|:|||.|...::::.|...:|:|||::.:..:|..|..::||..|:||||:.
Human   123 FNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSP 187

  Fly   152 DCVTA--SDMGKQNS--SDVFKTS-ADEFFHLEVLRI--STDISDLGGMVWEQLTALIITWIIIY 209
            :|..|  .|....:|  :|.|.|: |.|:|...||.:  |..|.|||...|:....|::..:::|
Human   188 NCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLY 252

  Fly   210 FCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQ 274
            |.|.:|:|:.||||:.|...||::|..||:||.|||||..||:.||..:::||.:..||.|||.|
Human   253 FSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQ 317

  Fly   275 MFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESV 339
            :.|.:|.|:|.::..:|::.|.||...|:::..|||..||..:||||||.||::::|..:|:..|
Human   318 VCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDV 382

  Fly   340 ATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWVRSHKCK 404
            |..|.||.|:.||||||.||:...||::||.||..|||||....:|::::.::||:..:..|:..
Human   383 AKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHREL 447

  Fly   405 LTLISCLIFLGLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFML 469
            .||...|....||....||||:::..|.|.:::..:::...|:|.|.|||.||:..|..|::.|.
Human   448 FTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMT 512

  Fly   470 GKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYPQWAIIIGWASCFTSVMWIPLYIF 534
            |:||:||||:.|::|:|..::|:::.|||..|...|....:|.||..:||....:|:..:|:|..
Human   513 GQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAA 577

  Fly   535 YIMIRKRATLCDSLKKRLKPLDWTPADPQ--DRAEYEAF 571
            |    |..:|..|.:::|........|.:  ||.|...|
Human   578 Y----KFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQF 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	216/536 (40%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	221/557 (40%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		9/32 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820