DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and slc6a1l

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_021330952.1	Gene:	slc6a1l / 568985	ZFINID:	ZDB-GENE-041210-296	Length:	578	Species:	Danio rerio

Alignment Length:	555	Identity:	217/555 - (39%)
Similarity:	346/555 - (62%)	Gaps:	13/555 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IERDEN----RGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLF 78
            :|..||    ||.||.|.:|:||.:|||||:||||||||||.::||.||||||...::.||||||
Zfish    17 VEEKENKIPDRGSWKGKFDFLLSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFTTLVFAGIPLF 81

  Fly    79 YMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWED 143
            .:|..:||::|.|..|::::.|::||.|:|.||::.:...||.:||::.:..:|.....::||:.
Zfish    82 LLETALGQYTSVGGLGVWKLIPMMKGVGLAAVVLSFWLNIYYIIIIAWALYYLFSSLKAELPWQT 146

  Fly   144 CSNSWNTDDCVTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTALIITWIII 208
            |.|.||||.|.  |:....::::: .::..||:...:.:::..:.:.|.:.|..:..|.::||::
Zfish   147 CDNPWNTDRCF--SNYSLLDTTNL-SSAVTEFWERNMHQLTNGLEEPGELRWPLVGTLALSWILV 208

  Fly   209 YFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAV 273
            ||.:.:|::..||||||:..:||.:||||..||.|||||..|:.||:.|.:::||..:||.|||.
Zfish   209 YFSIWKGVEWTGKVVYFSATYPYFMLFILFFRGVTLPGAIDGVLFYITPNFNKLLKSEVWLDAAT 273

  Fly   274 QMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVES 338
            |:||..|.|.|.::.:.|::||.||...|||::..||..||:.||.|:||::||:|..:..|:|.
Zfish   274 QIFFSYGLGLGSLIALGSYNSFNNNVYRDSVIVCCINSCTSMFAGIVIFSIVGFMSYITKRPIEE 338

  Fly   339 VATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWV-RSHK 402
            :|..|.||||:.||:|:..||:..|||::||.||.:||:||.|..:|..:::::||:..| |..|
Zfish   339 LAASGPGLAFLAYPQAVTQLPMSSLWAILFFSMLMMLGLDSQFCTVEGFITALMDEYPTVLRKRK 403

  Fly   403 CKLTLISCLI--FLGLSSIMCTNGGMFILQLFDWYS-SAIAVIVICLVEIIMVAWIYGIKNFMLD 464
            ....||.||:  .:|.|:|  |.||:::.:|||:|| |.:.::.:...|.|.:||.||.:.|..:
Zfish   404 KIFILIVCLVSFIIGFSNI--TQGGLYVFKLFDYYSASGMCLLFLVFFETISIAWFYGAEKFYKN 466

  Fly   465 VEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYPQWAIIIGWASCFTSVMWI 529
            :|.|:|.||..:|:..|...||.|.:.:...|.:.:..:|.....||.|...:||....:|::.|
Zfish   467 IEEMIGYRPCGFWKQCWIYFTPTICLGVFTFSAIEMTPLTLGKYVYPAWGQGVGWLMSLSSMVLI 531

  Fly   530 PLYIFYIMIRKRATLCDSLKKRLKPLDWTPADPQD 564
            |.||.|:....:..:.....|..||.:.|.:|..|
Zfish   532 PGYIIYMFFSTKGNIRQRWHKMTKPTELTTSDVND 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	209/533 (39%)
slc6a1l	XP_021330952.1	SLC5-6-like_sbd	15..558	CDD:320982	214/545 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820