DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and slc6a8

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001314797.1	Gene:	slc6a8 / 567544	ZFINID:	ZDB-GENE-071024-2	Length:	652	Species:	Danio rerio

Alignment Length:	623	Identity:	226/623 - (36%)
Similarity:	356/623 - (57%)	Gaps:	58/623 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NQPPTTNATRK--------------DKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLC 54
            |..|:.|.|..              :|:.|....|..|..:.:||:|.:|:|:|:||||||||||
Zfish    30 NAHPSVNGTLNGGPMSAATGAISAVEKKREGYPERETWTRQMDFIMSCVGFAVGLGNVWRFPYLC 94

  Fly    55 YRSGGAAFLIPYLLMVILAGIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCY 119
            |::||..|||||:|.:.|.|||:|::||.:|||...|...::.:.||.||.|.|.:|:..:|..|
Zfish    95 YKNGGGVFLIPYVLFIFLGGIPIFFLEIALGQFMKAGSINVWNIAPLFKGLGYASMVIVFFCNTY 159

  Fly   120 YSVIISYPIRMIFYCFFKK----VPWEDCSNSWNTDDCVTASDMGKQNSSDVFKTSAD------- 173
            |.:::::.    ||.|.|.    :||..|.|.|||::|:.....|...:..:..::..
Zfish   160 YIMVLAWG----FYYFIKSFNATLPWSTCDNPWNTENCIEIFRQGDCKNGTIGNSTFGNLTCEEL 220

  Fly   174 --------EFFHLEVLRISTDISDLGGMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFP 230
                    ||:..:||.||..:.:.|.:.||.:..|:..|:::|||:.:|:||.||:||||..||
Zfish   221 ANGRSPIIEFWENKVLNISDGLDEPGAVNWELMLCLLAVWVMVYFCVWKGVKSTGKIVYFTATFP 285

  Fly   231 YLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSF 295
            |::|.|||:||.|||||:.||.:|:.|:|.:|.:.:||.||..|:||....|.|.:..:.|::.|
Zfish   286 YVVLIILLVRGVTLPGAYDGILYYVKPDWSKLGEAQVWIDAGTQIFFSYAIGLGALTALGSYNRF 350

  Fly   296 RNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPV 360
            .|:...|:.::..||..||..|||||||:|||::.:.|:.:..||..|.||||:.||:|::::||
Zfish   351 NNDCYKDAFVLALINSGTSFFAGFVVFSILGFMASEQGVDISKVAESGPGLAFIAYPKAVSMMPV 415

  Fly   361 PQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEW---YWVRSHKCKLTLISCLIFLGLSSIMCT 422
            ..:||.:||.||.|||:||.||.:|..::.|||.:   |::|..:.....|.||:...:...|.|
Zfish   416 APVWAALFFIMLLLLGLDSQFVGVEGFVTGILDLFPGKYYMRYQREIAVAICCLLCFIIDLSMVT 480

  Fly   423 NGGMFILQLFDWYS-SAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTP 486
            .|||::.||||:|| |.:.::.....|.::|||:||...||.|:..|:|.||..:.:..|.::||
Zfish   481 QGGMYVFQLFDYYSASGMTLLWQAFWECVVVAWVYGADRFMDDIARMIGYRPFPWMKWCWSIITP 545

  Fly   487 VIIIFILITSIVFIRTITYNNI-PYPQWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKK 550
            .:.:.|.:..::..:.:||||: .||.|..:|||....:|::.||:.:.|.:...:.|..:..:.
Zfish   546 CVCMGIFLFHLLNYKPLTYNNVYVYPWWGEVIGWCLALSSMLCIPVSLVYKLSGAKGTFKERWEN 610

  Fly   551 RLKPLDWTPADPQDRAEYEAFRRQRRMPGFMSDTDMES 588
            ..||: |    .....||.|           .|||::|
Zfish   611 LTKPV-W----GAHHLEYMA-----------PDTDIKS 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	210/553 (38%)
slc6a8	NP_001314797.1	SLC6sbd_CT1	64..652	CDD:271397	220/589 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820