DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and slc6a2

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_009301625.1	Gene:	slc6a2 / 565776	ZFINID:	ZDB-GENE-110408-4	Length:	625	Species:	Danio rerio

Alignment Length:	557	Identity:	218/557 - (39%)
Similarity:	351/557 - (63%)	Gaps:	20/557 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PTTNA--TRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLM 69
            |::.|  :...:.|||:    .|..|.:|:||::|:|:.:.||||||||||::||.||||||:|.
Zfish    49 PSSRACTSASGEEIERE----TWGKKMDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYVLF 109

  Fly    70 VILAGIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYC 134
            :.:||:||||||:.:||::..|...::::.|:.||.|...:|:..|...||:|||::.:..::..
Zfish   110 LFIAGMPLFYMELALGQYNREGAATLWKICPVFKGVGYTVIVIALYVGFYYNVIIAWSLYYLYAS 174

  Fly   135 FFKKVPWEDCSNSWNTDDCVTASD-----MGKQNSSDVFK-TSADEFFHLEVLRI--STDISDLG 191
            ...::||..|:|.||:.:|....|     :|...|...:| |.|.||:...||..  |..|.|||
Zfish   175 LTSELPWLHCNNPWNSPNCTEPKDINGTVLGNGTSYAKYKNTPAAEFYERGVLHSHESKGIGDLG 239

  Fly   192 GMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLY 256
            ...||....|::...|:||.|.:|:||.|||||.|...||::|.:|||||.|||||..||:.||:
Zfish   240 LPRWELTICLVVVAFILYFSLWKGVKSSGKVVYITATMPYIVLLVLLIRGITLPGAMNGIRAYLH 304

  Fly   257 PEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVV 321
            .:..:|.:.:||.|||.|:||.:|.|:|.::..:|::.|.||...|::|..:||..||..:||.:
Zfish   305 IDLKKLNNPQVWIDAATQIFFSLGAGFGVLIAFSSYNKFNNNCYRDAILTSTINCVTSFFSGFAI 369

  Fly   322 FSVLGFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEA 386
            |||||:::|:..:.::.|||.||||.||.|||||:.||....:|::||.||..|||||....:||
Zfish   370 FSVLGYMAEQHKVNIKDVATEGAGLVFVIYPEAISTLPGATFFAIVFFIMLLTLGIDSSMGGMEA 434

  Fly   387 IMSSILDEWYWVRSHKCKLTLISCLIFLGLSSIMC-TNGGMFILQLFDWYSSAIAVIVICLVEII 450
            :::.:.|::..::.:: ||...:.::...|.:::| ||||:::|.|.|.|::..:::...|.|.|
Zfish   435 VLTGLSDDFKILKRNR-KLFTFATVVGTFLMALLCVTNGGIYVLTLLDKYAAGTSILFGVLFEAI 498

  Fly   451 MVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYPQWAI 515
            .|:|.||:..|..|:|.|:|.:|.:|||:.|:.|:|..::.::|.|||....:||:...:|.||.
Zfish   499 GVSWFYGVDRFSEDIERMMGFKPGIYWRLCWKFVSPAFLLLVVIASIVTSGRLTYDEYVFPYWAD 563

  Fly   516 IIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRL 552
            ::||:...:|::::|.|..|    |..::..|.|:||
Zfish   564 MLGWSIALSSMLFVPFYAIY----KFFSVPSSFKERL 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	213/538 (40%)
slc6a2	XP_009301625.1	SLC5-6-like_sbd	64..623	CDD:294310	214/542 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920