DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ntl and si:ch211-132b12.6

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001038523.1	Gene:	si:ch211-132b12.6 / 564583	ZFINID:	ZDB-GENE-050420-179	Length:	577	Species:	Danio rerio

Alignment Length:	536	Identity:	223/536 - (41%)
Similarity:	334/536 - (62%)	Gaps:	11/536 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEIL 83
            |..|.||.|..|:||:|::.|..:|:||||||||||||:||..||||||:.|:..|:|||.:|..
Zfish     6 EEIEERGFWGKKAEFLLAVAGNVVGLGNVWRFPYLCYRNGGGVFLIPYLVFVVTCGLPLFLLETA 70

  Fly    84 IGQFS-STGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSNS 147
            :|||: ..|.|...|:.||.:|.|.|..:...|...||::|:::.:..:...|..::||..|:|.
Zfish    71 MGQFTHEGGITCWHRLCPLAQGVGYAGQLTVLYSCMYYTIILAWALFYLVSSFSSQLPWVSCNNI 135

  Fly   148 WNTDDCV--TASDMGKQNSSDVFKTS-ADEFFHLEVLRISTDISDLGGMVWEQLTALIITWIIIY 209
            ||||:||  .|.::....::....|| |.||:...||.:|..|.|:|.:.||.|..||..|||.|
Zfish   136 WNTDNCVNLAAGNLTFNRTTLANSTSAATEFWERRVLSLSGGIEDIGKINWEILLCLIAMWIICY 200

  Fly   210 FCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQ 274
            ||:.:|:||.|||||||..|||::|.:|||||.|||||.:|:.||||||..||.|.:||.:|..|
Zfish   201 FCIWKGVKSTGKVVYFTATFPYVMLLVLLIRGLTLPGALQGVVFYLYPEPARLADPQVWMEAGTQ 265

  Fly   275 MFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESV 339
            :||......|.::::.|::.:.||...||..:..:|..||.:|||.|||||||::...|:|||.|
Zfish   266 VFFSYSVCSGILISLGSYNQYSNNCYRDSFWLCLLNSGTSFVAGFAVFSVLGFMAHVQGVPVEEV 330

  Fly   340 ATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWV--RSHK 402
            |..|.||||:.||:|:|::|.|||||:.||.|:.|||:||.||.:|.:::|::|.:..|  |:.:
Zfish   331 AESGPGLAFIAYPQAMAMMPFPQLWAVCFFIMIILLGLDSQFVGIECVITSVMDLFPEVLRRAGR 395

  Fly   403 CKL-TLISCL-IFLGLSSIMCTNGGMFILQLFDWYS-SAIAVIVICLVEIIMVAWIYGIKNFMLD 464
            .:| .|:.|| .|.| ..||.|.|||::.||||.|: :...::.:.:.|.:.:.|::|.:.....
Zfish   396 RELFVLLLCLTCFFG-QLIMVTEGGMYVFQLFDNYACNGACLLFLSVFESLAIGWLFGAEKMFDI 459

  Fly   465 VEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNN-IPYPQWAIIIGWASCFTSVMW 528
            :|.|...||..::.:.|:.:||::.:...:.|:|....:|:|. ..||.||..:||....:|::.
Zfish   460 IEDMTESRPNYWFMLCWKYLTPLVSLMSFVYSMVRYTPLTFNRWYVYPDWAYALGWLLALSSILL 524

  Fly   529 IPLYIFYIMIRKRATL 544
            :|.:....|...:.||
Zfish   525 VPGWALGQMWAGKGTL 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	221/531 (42%)
si:ch211-132b12.6	NP_001038523.1	SLC6sbd-TauT-like	11..550	CDD:271387	221/531 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920