DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ntl and si:ch211-225b11.1

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001103931.1	Gene:	si:ch211-225b11.1 / 561694	ZFINID:	ZDB-GENE-060531-39	Length:	609	Species:	Danio rerio

Alignment Length:	566	Identity:	225/566 - (39%)
Similarity:	354/566 - (62%)	Gaps:	20/566 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANNQPPTTNATRKDKRIERD--ENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFL 63
            :|........|||..| :|:.  |.|..|..:.||:|:.:|||:|:|||||||||||||||.|||
Zfish    30 LARTTTDRAEATRLAK-VEQQAAEPRETWGRRLEFVLATIGYAVGLGNVWRFPYLCYRSGGGAFL 93

  Fly    64 IPYLLMVILAGIPLFYMEILIGQFSSTG-CTGMFRMTPLLKGTGIAQVVVNAYCVC-YYSVIISY 126
            |||::|:.|.||||.:||..:||::..| ...:.::.||.||.|:|.||: :|.:| ||:|::::
Zfish    94 IPYMIMLFLCGIPLLFMEFTVGQYTRLGPVHALAQICPLFKGVGLATVVI-SYVLCTYYNVLMTW 157

  Fly   127 PIRMIFYCFFKKVPWEDCSNSWNT-DDCVTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDL 190
            .:..:.:.|...:||:.|:|:||| .:|.|    |...::...::::.:||..:||.:::.|...
Zfish   158 ALYYLLHSFSPSLPWQSCNNTWNTVANCST----GFPGNATHLQSASQQFFDHKVLEMTSGIERA 218

  Fly   191 GGMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYL 255
            ||:.||....|::.|.|:|||:.:|:||.|||||||..|||.:||.||:....||||..||.|:|
Zfish   219 GGVRWELFGLLVLAWGIVYFCIFKGVKSTGKVVYFTATFPYFILFALLVNNVQLPGAKNGILFFL 283

  Fly   256 YPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFV 320
            .|.|.:||:::||.:||.|:|..||..:|.:::|||::.:.||...|:.::...|..||::||||
Zfish   284 MPNWSKLLEVQVWVNAAAQIFNSIGISFGSMISMASYNKYNNNILRDTFIVSLANSATSIVAGFV 348

  Fly   321 VFSVLGFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLE 385
            :||.:|:::....:||:.:||.|.||.||.|||..:.:||.||||.:||.||..||:||.|..:|
Zfish   349 IFSAIGYMAHIHNLPVDDIATDGPGLVFVVYPEVFSTMPVSQLWAPLFFIMLLCLGLDSQFAMVE 413

  Fly   386 AIMSSILDEW------YWVRSHKCKLTLISCLIFLGLSSIMCTNGGMFILQLFDWYSSAIAVIVI 444
            ..::.|:|.:      .:.|.....|.:.|....||:..|  |.||:::.||.|.|::.::::.:
Zfish   414 VAVTFIMDGFGRKALKVFKRKELIVLAVCSFGFLLGIPHI--TRGGIYVFQLMDHYTAVVSLMFL 476

  Fly   445 CLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITY-NNI 508
            ...|::.|..|:|:|...:.||.||||:|.|::||.||.::|::::.|||:|||......| .:.
Zfish   477 AFFEVLAVTLIFGVKRLSVMVENMLGKKPNLFFRICWQYLSPMLVLGILISSIVQYTPARYGKSY 541

  Fly   509 PYPQWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKP 554
            .||.||.::||.....|::||||...:.:.....:|...|||.:.|
Zfish   542 TYPLWAELLGWFISLVSIIWIPLGALHELWTTEGSLLQRLKKSITP 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	217/539 (40%)
si:ch211-225b11.1	NP_001103931.1	SLC5-6-like_sbd	54..587	CDD:294310	217/539 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920