DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and slc6a11a

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001091857.1	Gene:	slc6a11a / 558960	ZFINID:	ZDB-GENE-030131-3729	Length:	590	Species:	Danio rerio

Alignment Length:	599	Identity:	228/599 - (38%)
Similarity:	354/599 - (59%)	Gaps:	35/599 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NATRKDKRIERD---ENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVI 71
            ::||:....:.|   |.||||.:|.||:|::.|..||:|||||||||||::||.||.|||:|.::
Zfish     4 SSTRRTGNQQADITPEERGQWANKIEFLLTVAGAIIGLGNVWRFPYLCYKNGGGAFFIPYVLYLV 68

  Fly    72 LAGIPLFYMEILIGQFSSTGCTGMFR-MTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCF 135
            ..|||||.:|..:||::|.|....:| :.||.:|.|.|..::..|....|.:||::....:|..|
Zfish    69 TCGIPLFVLETSLGQYTSQGGIMCWRKVCPLFEGMGYASQLIIVYGSITYIIIIAWAFLYLFSSF 133

  Fly   136 FKKVPWEDCSNSWNTDDCVTASDMGKQNSSDV-----FKTSADEFFHLEVLRISTDISDLGGMVW 195
            ..::||..|:|.||||.|:..|  |:.:||::     ..:|..||:|..|||:|:.:..||.:.|
Zfish   134 NVELPWASCNNPWNTDTCIVLS--GRNSSSELASPLNSSSSVMEFWHHRVLRLSSGVEHLGTVRW 196

  Fly   196 EQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWH 260
            :....|::.||::|||:.:|:||.||.||||..|||::|.|||:||.|||||..||.:|:||:..
Zfish   197 DLALILLLVWILVYFCIWKGVKSTGKAVYFTATFPYVMLLILLLRGVTLPGALNGIYYYMYPDLT 261

  Fly   261 RLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVL 325
            ||.|.:||.||..|:|:......|.:.::.|::.:.||...||..:..:|..||.|.||.:||||
Zfish   262 RLADPQVWMDAGTQIFYSYAICLGYLSSLGSYNQYNNNCYRDSFYLCLLNSGTSFLGGFAIFSVL 326

  Fly   326 GFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSS 390
            |.::::.|:.:..||..|.||.|:.||:|:.:||:.|.||:.||.|:.|||:||.||.||:||:|
Zfish   327 GHMAQEQGVDISLVAESGPGLVFIVYPQAVTMLPLSQFWAVCFFIMIILLGLDSQFVGLESIMTS 391

  Fly   391 ILDEWYWV--RSHKCKLTLIS-CLI--FLGLSSIMCTNGGMFILQLFDWY-SSAIAVIVICLVEI 449
            :.|.:..|  |..:.::.|:. ||:  |:||  :|.|.||::|:||||.| .|...::.:...:.
Zfish   392 VTDIFPTVLRRGFRREMLLLGICLVCYFMGL--LMITEGGLYIIQLFDHYVCSGTTLLFLATCQS 454

  Fly   450 IMVAWIYGIKNFMLDVEFMLGKRPTLYWRIV---WQVVTPVIIIFILITSIVFIRTITYNN-IPY 510
            :.:.|:||...|..:::.|:|.:|   |.:|   |..|||.:.:...|.|:|....:.:|| ..|
Zfish   455 VAIGWVYGADRFYENIQDMIGYKP---WPMVKYCWLYVTPSVCVGTFIFSLVKYSPLKFNNKYMY 516

  Fly   511 PQWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPLDWTPADPQDRAEYEAFRRQR 575
            |.||..|||....:|:..||:.:.|.:.:.:.|..:.|:....|.:..|...:..|.:..
Zfish   517 PWWAYGIGWFLAVSSLSLIPINMIYKLHKGKGTFWERLQLACSPAEDLPQSQRPSAHHYT----- 576

  Fly   576 RMPGFMSDTDMESS 589
                ..:.||.|.|
Zfish   577 ----LSASTDREKS 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	217/545 (40%)
slc6a11a	NP_001091857.1	SLC6sbd-TauT-like	21..560	CDD:271387	217/545 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820