DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and slc6a19a.1

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001091648.1	Gene:	slc6a19a.1 / 553256	ZFINID:	ZDB-GENE-070620-2	Length:	629	Species:	Danio rerio

Alignment Length:	580	Identity:	181/580 - (31%)
Similarity:	305/580 - (52%)	Gaps:	94/580 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KRIERDE--NRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLF 78
            :::|..|  .|.:|.:|::::|:.:|:.:|:||||||||||...||.||:||:|::::|.|:||.
Zfish    21 EKLELQEAGERPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGVPLL 85

  Fly    79 YMEILIGQFSSTGCTGMFR-MTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWE 142
            ::|..|||...:|..|::| ::|.|.|.|||.::.:.....||:.|:::.:..:|....:.:||.
Zfish    86 HLEFAIGQRLRSGSVGVWRSISPYLTGVGIASMLASFIVGMYYNTIMAWVMWYLFNSLQEPLPWS 150

  Fly   143 DCSNSWNTDDCVTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTALIITWII 207
            .|..:.|....|:..    :.||.|     |.|::.|.|..||.|.|.|.:.|..:..|:..|..
Zfish   151 QCPVNLNRTGLVSEC----ERSSPV-----DYFWYRETLNTSTAIEDSGALQWWLVLCLLCAWTF 206

  Fly   208 IYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAA 272
            :|.|.:|||::.||.||.|...||::|.|.|||..||.|:..||||...|:.:.|::...|.||.
Zfish   207 LYICCIRGIETTGKAVYITSTLPYVVLTIFLIRALTLKGSVNGIKFLFTPDVNELMNPSTWLDAG 271

  Fly   273 VQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKS----- 332
            .|:.|.....:||:::.:|::|..||.:.|:|.|..||..||:.:..|::|::||.:.::
Zfish   272 AQVLFSFSLAFGGLISFSSYNSVHNNCEQDAVTISIINGLTSVYSATVIYSIIGFRATENYDICL 336

  Fly   333 -----------GIPVESVATG------------------------------------GAGLAFVT 350
                       .:|..|:...                                    |.||||:.
Zfish   337 DSNILSLLNAFDLPEGSITENNYTVALQQLNISRPDIIQELQLKTCDMQTLLSEGVEGTGLAFIV 401

  Fly   351 YPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILD------EWYWVRSHKCKLTLIS 409
            :.|||..:||..||:::||.|||.||:.::|..:|.::..:.|      .|     .|...|.::
Zfish   402 FTEAITKMPVSPLWSVLFFIMLFCLGLSTMFGNIEGVVVPLQDLNLLPKRW-----PKEVFTGLT 461

  Fly   410 CLIFLGLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRPT 474
            |::....:.:...:.|.:.|.|||.::.:|.::||.|.|:|.|.::|||..|..|::||:|.:|.
Zfish   462 CVVSFLTALVFVQSSGNYWLALFDGFAGSIPLLVIALCELIAVVYVYGIDRFNEDIKFMVGHKPN 526

  Fly   475 LYWRIVWQVVTPVIIIFILITSIVFIRTI----TYN-------------NIPYPQWAIII 517
            ::|:|.|:.::|||::.|||  ..||.|:    |||             .:.||.|..::
Zfish   527 IFWQISWRFLSPVILLVILI--FYFITTVSKQLTYNVWDPQSADFPTLKEVDYPNWISVV 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	179/570 (31%)
slc6a19a.1	NP_001091648.1	SLC5-6-like_sbd	31..611	CDD:294310	179/570 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810