Protein Alignment Ntl and SLC6A15

DIOPT Version :9

• Sequence 1: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_877499.1
• Gene: SLC6A15 / 55117
• HGNCID: 13621
• Length: 730
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 192/620 - (30%)
• Similarity: 331/620 - (53%)
• Gaps: 107/620 - (17%)

  Fly    14 KDKRIER----DENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAG 74
            ||..:|.    ::.|..|.||.::||:.:|:::|:||||||||||.::||.|:|:|||:::::.|
Human    47 KDTDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIG 111

  Fly    75 IPLFYMEILIGQFSSTGCTGMFR-MTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKK 138
            ||||::|:.:||....|..|::. ::|.|.|.|.|..||..:...||:|||.:.:......|.:.
Human   112 IPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQP 176

  Fly   139 VPWEDC------SNSWNTDDCVTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQ 197
            :||:.|      |:::...:|       :|:|:..:      :::.|.|.||:.||:.||:.|:.
Human   177 LPWDQCPLVKNASHTFVEPEC-------EQSSATTY------YWYREALNISSSISESGGLNWKM 228

  Fly   198 LTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRL 262
            ...|:..|:::...:::||:|.||::||:..|||::|...|||...|.|:..||:....|:...:
Human   229 TICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIM 293

  Fly   263 LDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGF 327
            |:.|||.:||.|:||.:|.|:||::..:|::...||...|:||:..||.|||:||..|||:||||
Human   294 LEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGF 358

  Fly   328 ----LSEK-----------------------------SGIPVE---------------------- 337
                ::||                             |.:..|
Human   359 KANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPALHL 423

  Fly   338 ---------SVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILD 393
                     :.|..|.||||:.:.||:...|....|::|||.||..||:.|:|..:|.|::.|:|
Human   424 NSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVD 488

  Fly   394 EWYWVRSHKCKLTLISCLIFLGLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGI 458
            .:   :..|..||:|.||:...:..|.....|.:.:.:||.||:.:.::::.::|.|.|.::|||
Human   489 TF---KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGI 550

  Fly   459 KNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIV--FIRTITYNN----------IPYP 511
            ..||.|::.|||..|:.|:..:|:.::|::::.:||.|:|  .:....||.          :.||
Human   551 DKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYP 615

  Fly   512 QWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCD 546
            .|.:::    |.:.|::..|.:..:.|.:|..|.|
Human   616 TWGLVV----CVSLVVFAILPVPVVFIVRRFNLID 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	189/606 (31%)
SLC6A15	NP_877499.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	41..60		3/12 (25%)
		SLC6sbd_SBAT1	61..640	CDD:212091	186/598 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820