Protein Alignment Ntl and SLC6A20

DIOPT Version :9

• Sequence 1: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_001372612.1
• Gene: SLC6A20 / 54716
• HGNCID: 30927
• Length: 603
• Species: Homo sapiens
• Alignment Length: 627
• Identity: 193/627 - (30%)
• Similarity: 317/627 - (50%)
• Gaps: 112/627 - (17%)

  Fly    21 DENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEILIG 85
            ::.|..|.:..:|:.:.:.||:|:||||||||||...||.:||:||::|:|:.|:||.|:|:.:|
Human     2 EKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVG 66

  Fly    86 QFSSTGCTGMFR-MTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSNSWN 149
            |....|..|.:| ::|.|.|.|:|.|||:.:...||:||.::....:|:.|...:||..|..:.|
Human    67 QRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPLNGN 131

  Fly   150 ----TDDCVTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTALIITWIIIYF 210
                .::|..||             |...|::.:.|.||..:.:.||:.||....|::.|:::|.
Human   132 HTGYDEECEKAS-------------STQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYL 183

  Fly   211 CLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDL---------- 265
            |::||.:|.|||||||...||.:|.|.||||.||.||..|:.:...|:....|.|
Human   184 CILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKGSSALSLLAFQIEQLAN 248

  Fly   266 -KVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGF-- 327
             |.|.:||.|:||.:|.|:|.::..||::...||.:..::::..||.|||:.|..|.||:.||
Human   249 PKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKA 313

  Fly   328 ------------------------------LSEKSG-------------------IPVES---VA 340
                                          |.:..|                   ..:||   .|
Human   314 TFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESELDTA 378

  Fly   341 TGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWVRSH--KC 403
            ..|.||||:.|.|||..:.|.|||::::||||.:|||.|:.....||::.:.|... :.||  |.
Human   379 VQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKI-ISSHLPKE 442

  Fly   404 KLTLISCLIFLGLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFM 468
            .::.:.||:...:..:.....|.:...:|:.|::.:::::|.|||.|.|.::||::.|..|::.|
Human   443 AISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAM 507

  Fly   469 LGKRPTLYWRIVWQVVTPVIIIFILI---TSIVFIRTITYN----------NIPYPQWAIIIGWA 520
            .|:..:.||:::|..|:|::|:.:.:   :..:...|:.|.          ...||.:|:.:...
Human   508 TGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGL 572

  Fly   521 SCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPLDWTPADP 562
            ...:|.|.|||          |.|...:::|||..|   |||
Human   573 LVASSTMCIPL----------AALGTFVQRRLKRGD---ADP 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	188/614 (31%)
SLC6A20	NP_001372612.1	SLC6sbd_SIT1	2..588	CDD:271401	186/609 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810