DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ntl and slc6a5

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001009557.1	Gene:	slc6a5 / 494450	ZFINID:	ZDB-GENE-050105-2	Length:	786	Species:	Danio rerio

Alignment Length:	606	Identity:	241/606 - (39%)
Similarity:	368/606 - (60%)	Gaps:	46/606 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PPTTNATR----KDKRIERDEN--RGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLI 64
            |||.:..|    .|.....|||  ||.|.:|.:||||::|||:|:|||||||||.:::||.||||
Zfish   153 PPTDDTGRLFQDDDDDDGGDENKARGNWSNKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLI 217

  Fly    65 PYLLMVILAGIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIR 129
            |||:|:.|||||:|.:|:.:|||:|.|...:::..|.|:|.|||.::::.....||::|:.:.:.
Zfish   218 PYLIMLGLAGIPIFLLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNIIMCWTLY 282

  Fly   130 MIFYCFFKKVPWEDCSNSWNTDD---------------------------CVTASDMGKQNSSDV 167
            .:|....:.:||..|.|.|||.:                           |::|:.:|  |.|.:
Zfish   283 YLFASLKETLPWATCKNEWNTVECKDKDMLLLDTCILRDRNITSIKNTTFCLSANVVG--NLSKL 345

  Fly   168 FKTSAD---------EFFHLEVLRISTDISDLGGMVWEQLTALIITWIIIYFCLMRGIKSVGKVV 223
            ...:.|         |:|...||.||..|...|.:.|.....|.:.|:|:|..|.:||||.||||
Zfish   346 LNVTVDNKTYVSPSEEYFKYNVLHISKGIEYPGDIRWPLAACLFLAWLIVYASLAKGIKSSGKVV 410

  Fly   224 YFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVN 288
            |||..|||::|.||||||.|||||..||.:::.|:|.:|.|.|||.|||.|:||.:...|||::.
Zfish   411 YFTATFPYVVLVILLIRGVTLPGAGSGILYFITPKWEKLNDAKVWKDAATQIFFSLSAAWGGLIT 475

  Fly   289 MASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESVATGGAGLAFVTYPE 353
            ::|::.|.||...|::::...|..||:.||||:|||:||::.:..:|:||||..|.|:|||.|||
Zfish   476 LSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAHELKVPIESVADEGPGIAFVVYPE 540

  Fly   354 AIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEW-YWVRSHKCKLTLISCLIFLGLS 417
            |:..||:...||::||.||..||:|::|..:|.|::|:.||: .::|.||.:.||:.||.|..|.
Zfish   541 ALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSVSDEFPKYLRKHKPQFTLVCCLSFFVLG 605

  Fly   418 SIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQ 482
            ..|.|..||::|||.|.::::.::::|.:.|::.:::|||::.|..|:|.|:|.:|..:||:.|.
Zfish   606 FPMITESGMYMLQLVDTFAASYSLVIIAIFELVGISYIYGLQRFCEDIEMMIGFQPNKFWRVCWA 670

  Fly   483 VVTPVIIIFILITSIVFIRTITYNNIPYPQWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDS 547
            .|||.|:.|||..|:...:.:||.:..||.|::::||.....||:|||:.....|.....:|.:.
Zfish   671 FVTPTILTFILALSLYQWKVMTYEDYTYPNWSMVLGWLMVICSVIWIPIMFAIKMHLAPGSLIER 735

  Fly   548 LKKRLKPL-DWTPADPQDRAE 567
            ||....|. ||.|...:.|.|
Zfish   736 LKLVCSPQPDWGPFLMKHRGE 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	227/566 (40%)
slc6a5	NP_001009557.1	SLC5-6-like_sbd	177..775	CDD:294310	233/582 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100873
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820