Protein Alignment Ntl and SLC6A17

DIOPT Version :10

• Sequence 1: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_001010898.1
• Gene: SLC6A17 / 388662
• HGNCID: 31399
• Length: 727
• Species: Homo sapiens
• Alignment Length: 640
• Identity: 192/640 - (30%)
• Similarity: 321/640 - (50%)
• Gaps: 96/640 - (15%)

  Fly    14 KDKRIERD---ENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGI 75
            |.|.:|.:   |:|..|.||.::||:.:|:::|:||:|||||||.::||.|:|:|||:::|:.||
Human    47 KQKAVEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGI 111

  Fly    76 PLFYMEILIGQFSSTGCTGMFR-MTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKV 139
            |||::|:.:||....|..|::. :.|.|.|.|.:..:|..:...||:|||.:.|...|..|...:
Human   112 PLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPL 176

  Fly   140 PWEDCSNSWNTDDCVTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTALIIT 204
            ||.:|....|....|..::..|.:::..       |::.|.|.||..||:.||:.|:....|::.
Human   177 PWSECPVVRNGSVAVVEAECEKSSATTY-------FWYREALDISDSISESGGLNWKMTLCLLVA 234

  Fly   205 WIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWA 269
            |.|:...:::||:|.|||:||:..|||::|...|:||..|.||..||.....|:..::||.:||.
Human   235 WSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWR 299

  Fly   270 DAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGF------- 327
            :||.|:||.:|.|:||::..:|::...||...|:.|:..||.|||:||..|||:||||
Human   300 EAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNE 364

  Fly   328 --------------------------------LSEKSGIPVESV----------ATG-------- 342
                                            |:.|..:.:.:|          |.|
Human   365 KCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLED 429

  Fly   343 -------GAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWVRS 400
                   |.||||:.:.||:...|....|::|||.||..||:.|:...:..|.:.|:|.:...:
Human   430 ELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPK- 493

  Fly   401 HKCKLTLISCLIFLGLSSIM-CTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLD 464
               ::..:.|.:|..|..:: ....|.:.:.:||.||:.:.:.:|.::|.|.||||||.|.||.:
Human   494 ---EMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYGTKKFMQE 555

  Fly   465 VEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFI------------RTITYNNIPYPQWAIII 517
            :..|||.||..::..:|:.|:|:.:..:...||:.:            .......:.:|.||:.:
Human   556 LTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMAL 620

  Fly   518 GWASCFTSVMWIPLYI----FYIMIRKRATLCDSLKKRLKPLDWTPADPQDRAEY 568
            .......:.:.||:..    |:::.....||..|.||.....|.:..:..|...:
Human   621 LITLIVVATLPIPVVFVLRHFHLLSDGSNTLSVSYKKGRMMKDISNLEENDETRF 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:444915	186/611 (30%)
SLC6A17	NP_001010898.1	SLC6sbd_NTT4	60..648	CDD:271403	181/598 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..727