DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ntl and slc6a22.1

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_005166076.1	Gene:	slc6a22.1 / 368923	ZFINID:	ZDB-GENE-030616-629	Length:	584	Species:	Danio rerio

Alignment Length:	546	Identity:	220/546 - (40%)
Similarity:	333/546 - (60%)	Gaps:	14/546 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEILIGQFS 88
            ||||.||.||||::.|..||:|||||||||||::||..|.|||::.:...|||||.||..:||::
Zfish    30 RGQWSSKVEFILAVAGQIIGLGNVWRFPYLCYKNGGGVFFIPYVVFLFACGIPLFLMETALGQYT 94

  Fly    89 STGCTGMFR-MTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSNSWNTDD 152
            |.|....:| :.||.:|.|....||..|...||.:|:::....:|..|..::||..|.|.||:::
Zfish    95 SQGSVTCWRKICPLFEGLGYGSQVVVLYSSAYYIIILAWAFFYLFSSFSGELPWASCRNWWNSEN 159

  Fly   153 CVTASDM-GKQNSSDVFKTSA--DEFFHLEVLRISTDISDLGGMVWEQLTALIITWIIIYFCLMR 214
            ||....| |.:|.|.:...|:  .||:...||.|:..:::||.:.||....|::.|:|.|||:.:
Zfish   160 CVEFDRMQGAKNLSFMANASSPVKEFWERRVLNITGSVNELGSVRWELALCLLLAWVICYFCVWK 224

  Fly   215 GIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFGI 279
            |:||.|||||||..|||::|.:|||||.|||||..||.|||||...||.|.:||.||..|:|:..
Zfish   225 GVKSTGKVVYFTATFPYVMLMVLLIRGLTLPGAIDGITFYLYPNPARLADPQVWMDAGTQIFYSY 289

  Fly   280 GPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESVATGGA 344
            ....|.:..:.|::.:.||...|.|.:..:|..||.:|||.:||||||::.:.|:.:..||..|.
Zfish   290 ALCIGCLTALGSYNKYNNNCYKDCVYLCLLNSGTSFVAGFAIFSVLGFMALEQGVDISVVAESGP 354

  Fly   345 GLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILD--EWYWVRSHKCKL-T 406
            ||||:.||.|:|::|:.|||::.||.|:.|||:||.||.||::|::|.|  ..::::.|:.|| .
Zfish   355 GLAFIAYPRAVAMMPMAQLWSICFFLMIILLGLDSEFVGLESLMTAITDMNPNFFLQGHRRKLFL 419

  Fly   407 LISCLIFLGLSSIMCTNGGMFILQLFDWYS-SAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLG 470
            |:.|:....:..:|.|.||:::.||||:|| |.:.:::..:.:.|.:.|.||......::..|:|
Zfish   420 LVICIACFLIGLLMVTEGGLYVFQLFDYYSCSGMTLLLFAIAQSICIGWFYGADRLYENIADMIG 484

  Fly   471 KRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNN-IPYPQWAIIIGWASCFTSVMWIPLYIF 534
            ..|....:..|:.:||::.|...|.|:|....:.:|| ..||.|....||....:|.:.:|:::.
Zfish   485 YHPLTLMKYCWKYITPIVCIGTFIFSLVKFTPLKFNNTYEYPWWGYAAGWWFTLSSTLLVPIWMI 549

  Fly   535 YIMIRKRATLCDSLKKRLKPLDWTPA 560
            |.::....|    ||:||:.| .|||
Zfish   550 YAILVTPGT----LKQRLRVL-CTPA 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	216/538 (40%)
slc6a22.1	XP_005166076.1	SLC6sbd-TauT-like	30..569	CDD:271387	217/543 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820