Protein Alignment Ntl and DAT

DIOPT Version :9

• Sequence 1: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Alignment Length: 648
• Identity: 242/648 - (37%)
• Similarity: 363/648 - (56%)
• Gaps: 86/648 - (13%)

  Fly     1 MANNQPPTTNATRKDKRIERDEN-----RGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGA 60
            ::.::.||.:        :.|.|     |..|..|.:|:||::|:|:.:.||||||||||::||.
  Fly     7 ISKSKTPTPH--------DNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGG 63

  Fly    61 AFLIPYLLMVILAGIPLFYMEILIGQFSSTG---CTGMFRMTPLLKGTGIAQVVVNAYCVCYYSV 122
            |||:||.:|:::.||||||||:.:||.:..|   |.|  |:.||.||.|.|.|::..|...||:|
  Fly    64 AFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWG--RLVPLFKGIGYAVVLIAFYVDFYYNV 126

  Fly   123 IISYPIRMIFYCFFKKVPWEDCSNSWNTDDC--------------VTASD---MGKQ-------- 162
            ||::.:|..|..|...:||..|:|.|||.:|              ...||   ||.|
  Fly   127 IIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETY 191

  Fly   163 -NSSDV----------FKTSADEFFHLEVLRI--STDISDLGGMVWEQLTALIITWIIIYFCLMR 214
             |.|.:          |:::|.|:|:..:|.:  |..|.|||.:.|:....|:|.::|.||.|.:
  Fly   192 MNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWK 256

  Fly   215 GIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFGI 279
            ||.:.||||:||..|||.:|.||||||.||||::.||::||.|.:..:...:||.|||.|:||.:
  Fly   257 GISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSL 321

  Fly   280 GPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESVATGGA 344
            |||:|.::..||::.:.||...|::|...||..||.:||||:|||||:::...|:.:|.|||.|.
  Fly   322 GPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGP 386

  Fly   345 GLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWVRSHKCKLT--L 407
            ||.||.||.|||.:|....|||:||.||..||:||.|...|||::::.||:..::.::....  |
  Fly   387 GLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGL 451

  Fly   408 ISCLIFLGLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKR 472
            .|....:||:|  ||.||.:...|.|.|::..:::|....|.|.|:||||...|..|:..|:|..
  Fly   452 FSLYFVVGLAS--CTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFP 514

  Fly   473 PTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYPQWAIIIGWASCFTSVMWIPLYIFYIM 537
            |..||::.|:.|.|:.::||.:..::....:||.:..||.||..:||....:||:.||.    :.
  Fly   515 PGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPA----VA 575

  Fly   538 IRKRATLCDSLKKRLKPLDWTPADPQDRAEYEAFRRQRRMPGFMSD----------TDMESSK 590
            |.|..:...||::|...|. ||           :|.|:.|...::.          ||.|::|
  Fly   576 IFKLLSTPGSLRQRFTILT-TP-----------WRDQQSMAMVLNGVTTEVTVVRLTDTETAK 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	228/572 (40%)
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	231/589 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440810
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850