DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and CG8850

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	584	Identity:	210/584 - (35%)
Similarity:	327/584 - (55%)	Gaps:	28/584 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEIL 83
            |....|.||....||:.|.:..::|:|||||||::...:||.||||||:::::|.|.|::|:|::
  Fly    52 ESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVI 116

  Fly    84 IGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSNSW 148
            ||||||.||...|.|.|:::|....||...|....||:.|::..||.:...|.:.:||..|...|
  Fly   117 IGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWTYCLVEW 181

  Fly   149 NTDDCVTASDMGKQNSSDVFK--TSADEFFHLEVLR--ISTDISDLGGMVWEQLTALIITWIIIY 209
            . ..|| |:.....|.|.:.:  :||:.||...|||  .|.|.:.||...|:.:..|:.||:||.
  Fly   182 G-KSCV-ATGATAANDSSIVQGVSSAELFFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVIIG 244

  Fly   210 FCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQ 274
            ..|.:||:|.||..||...|||:::.:||||..||||||:||.::|.|:|.:||:..||..|..|
  Fly   245 TILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQ 309

  Fly   275 MFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLS-EKSGIPVES 338
            |||.:...:|.:|..|||:.|..|...|.::|.:|:..||:|||.::|.:||.|: |.:...:..
  Fly   310 MFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQ 374

  Fly   339 VATGGAGLAFVTYPEAIALLP-VPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEW----YWV 398
            |..|||||||::||||||... :|||:|::|||||.:|||.|......|:::.:.|.:    :|:
  Fly   375 VVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRFTHLPHWL 439

  Fly   399 RSHKCKLTLISCLIFLGLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFML 463
            .:....:....|    ||  :..|.||.|:|.|.|:|......:|:.:.|::.|.||||:|....
  Fly   440 LAVSASIIGFLC----GL--VYMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVGWIYGVKRICS 498

  Fly   464 DVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYPQWAIIIGWASCFTSVMW 528
            |:||||..:.:.||||.|.:|.|.::..:|:..:.....:||..:.||....:.||......|:.
  Fly   499 DIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMAGWIIWGLGVLQ 563

  Fly   529 IPLYIFYIMIRKRA-TLCDSLKKRLKP-LDWTPADPQDRAEYEAFRRQRRMPGFMSDTDMESSK 590
            :|.:....:.::.. |........::| .:|.|...|   ::||:...|:     .:.|.:|.:
  Fly   564 LPFWALVTIYQQPGKTFGSKFGLAMQPTANWGPLQTQ---KFEAYIIHRK-----READFKSPR 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	200/540 (37%)
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	190/481 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440757
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850