Protein Alignment Ntl and SLC6A18

DIOPT Version :9

• Sequence 1: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_872438.2
• Gene: SLC6A18 / 348932
• HGNCID: 26441
• Length: 628
• Species: Homo sapiens
• Alignment Length: 639
• Identity: 203/639 - (31%)
• Similarity: 329/639 - (51%)
• Gaps: 101/639 - (15%)

  Fly    22 ENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEILIGQ 86
            :.|.:|.:|::::||..|:|:|:||:|||||||...||.||||||::.::..|||:|::|:.|||
Human    16 DERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELAIGQ 80

  Fly    87 FSSTGCTGMF-RMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSNSWN- 149
            ....|..|:: .::|.|.|.|:..|.::.....||:.|:::.:..:...|...:||..|....|
Human    81 RLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSCPPDLNR 145

  Fly   150 ---TDDCVTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTALIITWIIIYFC 211
               .::|        |.||.|     ..|::.:.|.|:.||:|.|.:.|..|..|..:|.::|.|
Human   146 TGFVEEC--------QGSSAV-----SYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMC 197

  Fly   212 LMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMF 276
            ::|||::.|||:|||..||||:|.|.||||.|||||.||:.:...|..|.|.:.:||.|||.|:|
Human   198 VIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDAATQIF 262

  Fly   277 FGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGF-------------- 327
            |.:...:||.:..||::|.||:.:.|:|:|..:|..|||.|...|||||||
Human   263 FSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNI 327

  Fly   328 --LSEKSGIPVESV------------------------------------ATGGAGLAFVTYPEA 354
              |......|.:|:                                    :..|.|||||.:.|.
Human   328 LSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTET 392

  Fly   355 IALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWY---WVRSHKCKLTLISCLIFLGL 416
            ...:|...:||::||.|||.||:.::|..:||:::.:||...   ||  .|..||.:.||:....
Human   393 DLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVLPRWV--PKEALTGLVCLVCFLS 455

  Fly   417 SSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVW 481
            ::......|.:.|::||.::::..::::..:|::.|.::||:|.|..|:.:|.|:||:.|||:.|
Human   456 ATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTW 520

  Fly   482 QVVTPVII-IFILITSIVFIRTITYNN-------IPYPQWAIIIGW--ASC----FTSVMWIPLY 532
            :||:|::: ||:....::|.:.:.|..       .|..|..:..||  |:|    ...|:|:|:
Human   521 RVVSPLLLTIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPV- 584

  Fly   533 IFYIMIRKRATLCDSLKKRLKPLDWTPADPQDRAEYEAFRRQRRMPGFMSDTDM 586
                     |.|...|.:|.:  .|...|.:...:.......|.......||||
Human   585 ---------AALAQLLTRRRR--TWRDRDARPDTDMRPDTDTRPDTDMRPDTDM 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	196/603 (33%)
SLC6A18	NP_872438.2	SLC6sbd_B0AT3	17..591	CDD:212086	194/598 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	602..628		6/26 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810