DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and CG13794

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_609137.2	Gene:	CG13794 / 34048	FlyBaseID:	FBgn0031936	Length:	595	Species:	Drosophila melanogaster

Alignment Length:	611	Identity:	151/611 - (24%)
Similarity:	283/611 - (46%)	Gaps:	76/611 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYM 80
            |....|..||:|...:::|.:..|.|:.: :::...|..:...|...::|||:.:::..:|:..:
  Fly    12 KPFSPDLKRGKWDKPTDYIFACFGLALKL-DIFVASYWFFFDMGIFGMLPYLVYMVIYLVPIMVI 75

  Fly    81 EILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCS 145
            ...:|||||:|....||::|..||.|...|.:....:.|||:..:.|:..:...|...:|| .|.
  Fly    76 HSFMGQFSSSGFISAFRLSPFFKGMGYVSVFLTISMLIYYSIFAAVPLLFMINSFRPTLPW-SCE 139

  Fly   146 --NSW--NTDDCVTASDM--------GKQNSSDV----FKTSADEFF--HLEVLRISTDISDLG- 191
              .||  .:|..:|..:|        ...|::|.    |...:..:|  |.|.:: ..:.|||.
  Fly   140 GFKSWYNESDGKMTTCNMTISEDLTDNSDNNTDFHRPHFHVPSVLYFLKHFESVQ-EENYSDLRQ 203

  Fly   192 --GMVWEQLTALIITWIIIYFCLMRGIKSV--GKVVYFTVPFPYLLLFILLIRGATLPGAWKGIK 252
              .:.|..::..::.|.::.|...:..::.  ||.:.:.|....:||.:...|...||||..|::
  Fly   204 DYDLSWRFVSLFVLVWAMVAFIFYKFSETAMFGKFIRYMVIGTLILLLVCFGRFLFLPGALLGLR 268

  Fly   253 FYLYPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLA 317
            .|:.|....:. :.: ....|.:....|.|||.::.::||:.|:.:....|.:|....:|...:.
  Fly   269 KYVTPSPDEIA-MGI-GSTFVMVLHAFGAGWGSVIALSSFNGFKTDIMSYSWIISFGQIFIFTMF 331

  Fly   318 GFVVFSVLGFLSEK-SGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVF 381
            |.|.:.:..:.:|. .|...:.|.|..|  .:::...|::.|..|.||..:::.||.:..:..:.
  Fly   332 GLVSYMLDHYYNEGIEGSFDKQVLTHWA--LYLSSATALSSLGWPNLWTFIYYTMLLMAALIVIT 394

  Fly   382 VQLEAIMSSILDEWYWVRSHKCKLTLISCLIFLGL-------SSIMCTNGGMFILQLFDWYSSAI 439
            .|:..::.|:.||:..:|..|.::|       .||       |...|||.|:       .:.||:
  Fly   395 TQIFTVLQSLFDEFEVLRVRKQEVT-------FGLIGGIAVCSFYFCTNHGI-------TFFSAL 445

  Fly   440 AVIVIC------LVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRI-VWQVVTPVIIIFILITSI 497
            |:..|.      |:.:::|.||||.:.|..|:||||| :|...|:: :.:.:.|:|:|..|:..|
  Fly   446 ALDAIFSHSLLHLLLLLVVLWIYGRERFQRDIEFMLG-QPFASWKVYILRFIAPIILIICLVVGI 509

  Fly   498 VFIRTITYNNIPYPQWAIIIGWASCFT--SVMWIPLYIFYIMIRKRATLCDSLKKRLKPLDWTPA 560
            :    :.|....|.. ||::|.:....  .::.||.|..|.:.|...:.|:..|:..:|.||.|.
  Fly   510 L----VCYMEHIYSS-AIVLGMSIILVILPILAIPGYGIYYIYRSTGSFCERFKRTCRPTDWYPV 569

  Fly   561 DPQDRAEYEAFRRQRRMPGFMSDTDM 586
            :.:.|.:||.         .:|:|||
  Fly   570 EMEHRQQYEE---------AVSNTDM 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	138/569 (24%)
CG13794	NP_609137.2	SLC5-6-like_sbd	27..509	CDD:271356	122/503 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440819
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840