DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and SLC6A19

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001003841.1	Gene:	SLC6A19 / 340024	HGNCID:	27960	Length:	634	Species:	Homo sapiens

Alignment Length:	602	Identity:	198/602 - (32%)
Similarity:	313/602 - (51%)	Gaps:	98/602 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IERDE--NRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYM 80
            ||::|  :|.:|.:|::::|:.||:.:|:||||||||||...||.||:||:|::::|.||||.|:
Human    24 IEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYL 88

  Fly    81 EILIGQFSSTGCTGMF-RMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDC 144
            |..|||....|..|:: .:.|.|||.|:|.::.:.....||:.|||:.:..:|..|.:.:||.||
Human    89 EFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDC 153

  Fly   145 SNSWN----TDDCVTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTALIITW 205
            ..:.|    .|:|..:|.:             |.|::.|.|.|||.|||.|.:.|..|..|...|
Human   154 PLNENQTGYVDECARSSPV-------------DYFWYRETLNISTSISDSGSIQWWMLLCLACAW 205

  Fly   206 IIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWAD 270
            .::|.|.:|||::.||.||.|...||::|.|.||||.||.||..||.|...|....|.....|.|
Human   206 SVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLD 270

  Fly   271 AAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGF-------- 327
            |..|:||.....:||:::.:|::|..||.:.|||::..||.|||:....||:||:||
Human   271 AGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDD 335

  Fly   328 -------------------LSEKSGIPVE-------------------------SVATGGAGLAF 348
                               :::::.:.::                         |.|..|.||||
Human   336 CFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAF 400

  Fly   349 VTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILD------EWYWVRSHKCKLTL 407
            :.:.|||..:|:..||:::||.|||.||:.|:|..:|.::..:.|      :|     .|..||.
Human   401 IVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKW-----PKEVLTG 460

  Fly   408 ISCLIFLGLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKR 472
            :.||....:..|...|.|.:.|.|.|.|:.:|.:::|...|:..|.::||:..|..|:|||:|.:
Human   461 LICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHK 525

  Fly   473 PTLYWRIVWQVVTP--VIIIFILITSIVFIRTITYN-------------NIPYPQWAIIIGWASC 522
            |.::|::.|:||:|  ::|||:....:...:.:||:             .|.||.|..::.....
Human   526 PNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVA 590

  Fly   523 FTSVMWIPLYIFYIMIR 539
            ....:.||.|..|.:||
Human   591 GVPSLTIPGYAIYKLIR 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	195/594 (33%)
SLC6A19	NP_001003841.1	SLC5-6-like_sbd	32..612	CDD:294310	195/594 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810